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Subjects were exposed to an altitude of 24,000\u2009ft. for 90\u2009min, with either prior eccentric exercise (ECC) or no exercise (Control) 24\u2009h before. Blood samples were collected at baseline (T<jats:sub>0<\/jats:sub>), before (T<jats:sub>1<\/jats:sub>), and after (T<jats:sub>2<\/jats:sub>) altitude exposures. VGE load was evaluated using the Eftedal\u2010Brubakk (\u0395\u0392) scale. Creatine kinase (CK) and myoglobin were used to assess muscle damage, while interleukin\u20106 (IL\u20106), tumor necrosis factor alpha (TNF\u2010\u03b1), C\u2010reactive protein (CRP), and fibrinogen were used to evaluate inflammation. ECC showed higher EB\u2010scores during altitude exposures [median(range), 3(0\u20135)] than Control [1(0\u20134), <jats:italic>p<\/jats:italic>\u2009=\u20090.019]. Increases in myoglobin (+35%, <jats:italic>p<\/jats:italic>\u2009=\u20090.012), CK (+130%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), IL\u20106 (+72%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02), and CRP (+63%, <jats:italic>p<\/jats:italic>\u2009=\u20090.004) were observed from T<jats:sub>0<\/jats:sub> to T<jats:sub>1<\/jats:sub> in ECC, but not Control. Significantly higher levels of myoglobin (<jats:italic>p<\/jats:italic>\u2009=\u20090.033), CK (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), IL\u20106 (<jats:italic>p<\/jats:italic>\u2009=\u20090.016), and CRP (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) were noted in the ECC compared to Control at T<jats:sub>1<\/jats:sub>. IL\u20106 increased from T<jats:sub>1<\/jats:sub> to T<jats:sub>2<\/jats:sub> in ECC (<jats:italic>p<\/jats:italic>\u2009=\u20090.005), with higher levels than Control at T<jats:sub>2<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009=\u20090.046). A correlation was found between EB\u2010scores and T<jats:sub>1<\/jats:sub> myoglobin levels (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>\u2009=\u20090.450; <jats:italic>p<\/jats:italic>\u2009=\u20090.004), and to T<jats:sub>1<\/jats:sub>\u2010T<jats:sub>2<\/jats:sub> IL\u20106 changes (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>\u2009=\u20090.396; <jats:italic>p<\/jats:italic>\u2009=\u20090.037). Eccentric EIMD followed by inflammation is associated with a higher decompression strain, with VGE load aggravating systemic inflammation.<\/jats:p>","DOI":"10.14814\/phy2.70147","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T01:50:44Z","timestamp":1734054644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Eccentric exercise\u2010induced muscle damage and inflammation in conjunction with high\u2010altitude decompression in adults"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2623-2737","authenticated-orcid":false,"given":"Frode","family":"Gottschalk","sequence":"first","affiliation":[{"name":"Division of Environmental Physiology Swedish Aerospace Physiology Center, KTH Royal Institute of Technology  Stockholm Sweden"},{"name":"Department of Neuroscience, Experimental Traumatology KI Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Gennser","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology KI Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2372-6114","authenticated-orcid":false,"given":"Mattias","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Experimental Traumatology KI Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9738-9320","authenticated-orcid":false,"given":"Ola","family":"Eiken","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology KI Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5991-0733","authenticated-orcid":false,"given":"Antonis","family":"Elia","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology KI Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c02909"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3357\/amhp.5938.2022"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3357\/amhp.5207.2019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2011.02.013"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20107793.1998.305bo.x"},{"issue":"7","key":"e_1_2_9_7_1","first-page":"666","article-title":"Aerobic exercise 2 hours before a dive to 30 msw decreases bubble formation after decompression","volume":"76","author":"Blatteau J. 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