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The hemodynamic responses to peak exercise in MS are unknown. Further, it is unknown if the hemodynamic responses are due to disease or fitness. Therefore, the purpose was to compare hemodynamic response to peak exercise between individuals with and without MS, with similar peak VO<jats:sub>2<\/jats:sub>. Individuals with MS (<jats:italic>n<\/jats:italic>\u2009=\u200921) and CON (<jats:italic>n<\/jats:italic>\u2009=\u200921) underwent maximal incremental cycle exercise test to assess peak aerobic capacity (peak VO<jats:sub>2<\/jats:sub>). Heart rate, stroke volume, cardiac output, and blood pressure were obtained every other minute of the exercise test. There were no significant group differences in peak VO<jats:sub>2<\/jats:sub>. All hemodynamic variables increased similarly from baseline to peak exercise in both MS and CON. There was a significant group by time interaction for HR in individuals with MS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), accounted for by age, but no group by time interactions in MAP (<jats:italic>p<\/jats:italic>\u2009=\u20090.78), SV (<jats:italic>p<\/jats:italic>\u2009=\u20090.11), or Q (<jats:italic>p<\/jats:italic>\u2009=\u20090.86). Our findings suggest that individuals with and without MS, with similar peak VO<jats:sub>2<\/jats:sub>, have similar hemodynamic responses to peak exercise. Our data suggest that fitness is a key underlying determinants of hemodynamics responses in individuals with MS.<\/jats:p>","DOI":"10.14814\/phy2.70150","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T03:43:26Z","timestamp":1735271006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cardiovascular hemodynamic response to peak exercise in individuals with multiple sclerosis"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2830-4482","authenticated-orcid":false,"given":"Brooks A.","family":"Hibner","sequence":"first","affiliation":[{"name":"Integrative Physiology Laboratory University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9430-1557","authenticated-orcid":false,"given":"Natalia 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USA"},{"name":"Department of Exercise and Health Sciences University of Massachusetts Boston  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Fernhall","sequence":"additional","affiliation":[{"name":"Integrative Physiology Laboratory University of Illinois at Chicago  Chicago Illinois USA"},{"name":"Department of Exercise and Health Sciences University of Massachusetts Boston  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.01.009"},{"key":"e_1_2_9_3_1","volume-title":"ACSM's guidelines for exercise testing and prescription","author":"American College of Sports 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