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The temporal profile of thiol\u2010oxidized albumin, a marker of oxidative stress, has shown potential in assessing recovery from EIMD in non\u2010athletically trained participants but not yet in trained participants. Our primary aim was to assess whether there are changes in the level of thiol\u2010oxidized albumin after a marathon in athletically trained participants. Twenty participants completed a marathon and collected daily dried blood spots from 3\u2009days prior to and 7\u2009days after the marathon to measure thiol\u2010oxidized albumin using a novel methodology (OxiDx). Participants were also assessed for indirect markers of EIMD prior to and on days 2 and 5 post\u2010marathon. The level of thiol\u2010oxidized albumin peaked at 2\u2009days and remained elevated until 5\u2009days after the marathon and correlated with indirect measures of EIMD. Furthermore, time of recovery for thiol\u2010oxidized albumin varied between participants, some recovered at 3 days post\u2010marathon whereas others extended beyond 7\u2009days post marathon. Tracking temporal changes in the level of thiol\u2010oxidized albumin has potential to be useful in managing recovery from EIMD in athletes, particularly considering the ease of the OxiDx methodology.<\/jats:p>","DOI":"10.14814\/phy2.70155","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T03:24:31Z","timestamp":1735356271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Temporal changes in thiol\u2010oxidized plasma albumin are associated with recovery from exercise\u2010induced muscle damage after a marathon"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0854-8041","authenticated-orcid":false,"given":"Christopher","family":"James","sequence":"first","affiliation":[{"name":"Proteomics International  Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9472-3450","authenticated-orcid":false,"given":"Erin M.","family":"Lloyd","sequence":"additional","affiliation":[{"name":"School of Human Sciences (Department of Anatomy, Physiology and Human Biology) The University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1257-8200","authenticated-orcid":false,"given":"Peter G.","family":"Arthur","sequence":"additional","affiliation":[{"name":"School of Molecular Sciences The University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.10.023"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10081241"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/JSC.0000000000000232"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182111258"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15480"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000003167"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/sports8030035"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldm014"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1179\/135100005X83716"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scispo.2022.04.003"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.734229"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0271233"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2015.97"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2006.03.012"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/02640410600718228"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.128827"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000000249"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-100281"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057602"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00768"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.278.2.E352"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2011.12.002"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asmr.2021.09.034"},{"key":"e_1_2_11_25_1","first-page":"807","article-title":"Reference change values","volume":"50","author":"Fraser C. 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