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The contribution of elevated MSNA to the vasodilatory response during passive leg movement (PLM) is not fully understood. This study tested the hypothesis that elevated MSNA diminishes the vasodilatory response to PLM in healthy young males (<jats:italic>n<\/jats:italic>\u2009=\u200911, 25\u2009\u00b1\u20092\u2009yr). Post exercise circulatory occlusion (PECO) following 2\u2009min of isometric handgrip (HG) exercise performed at 25% (ExPECO 25%) and 40% (ExPECO 40%) maximum voluntary contraction was used to incrementally engage the metaboreceptors and augment MSNA. Control trials were performed without PECO (ExCON 25% and ExCON 40%) to account for changes due to HG exercise. PLM was performed 2\u2009min after exercise and hemodynamics were assessed. MSNA was recorded by microneurography in the peroneal nerve (<jats:italic>n<\/jats:italic>\u2009=\u20098). Measures of MSNA (i.e., burst incidences) increased during ExPECO 25% (+15\u2009\u00b1\u20095 burst\/100\u2009bpm) and ExPECO 40% (+22\u2009\u00b1\u20094 burst\/100\u2009bpm) and returned to pre\u2010HG levels during ExCON trials. Leg vascular conductance (vasodilation) during PLM was reduced by 16% and 44% during ExPECO 25% and ExPECO 40%, respectively. These findings indicate elevated MSNA attenuates the vasodilatory response to PLM and the magnitude of reduction in vasodilation during PLM is graded with the degree of sympathoexcitation.<\/jats:p>","DOI":"10.14814\/phy2.70180","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T06:06:16Z","timestamp":1741759576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Acute sympathetic activation blunts the hyperemic and vasodilatory response to passive leg movement in young healthy males"],"prefix":"10.14814","volume":"13","author":[{"given":"Brady E.","family":"Hanson","sequence":"first","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center George E. Whalen VA Medical Center  Salt Lake City Utah USA"},{"name":"Department of Internal Medicine, Division of Geriatrics University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua F.","family":"Lee","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center George E. Whalen VA Medical Center  Salt Lake City Utah USA"},{"name":"Department of Internal Medicine, Division of Geriatrics University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan S.","family":"Garten","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center George E. Whalen VA Medical Center  Salt Lake City Utah USA"},{"name":"Department of Kinesiology and Health Sciences Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Barrett\u2010O'Keefe","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center George E. Whalen VA Medical Center  Salt Lake City Utah USA"},{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota USA"},{"name":"Mayo Clinic School of Health Sciences, Mayo Clinic College of Medicine and Science Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenael","family":"Layec","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Geriatrics University of Utah  Salt Lake City Utah USA"},{"name":"School of Health and Kinesiology University of Nebraska Omaha  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Ruple","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center George E. 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