{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:47:06Z","timestamp":1790833626080,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001109","name":"Flinn Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intermittent hypoxia has been used to enhance oxygen delivery in athletes and patients; however, it is unclear whether acute exposure is sufficient to elicit lasting physiologic adaptation(s). The purpose of this study was to evaluate physiologic response(s) to hypobaric\u2010hypoxic (HH) exercise. Nine participants (4\u2009M\/5F; 37.9\u2009\u00b1\u200912.7\u2009yrs.; 174.3\u2009\u00b1\u20099.4\u2009cm; 75.3\u2009\u00b1\u200915.9\u2009kg; 24.4\u2009\u00b1\u20093.4\u2009kg\/m<jats:sup>2<\/jats:sup>) were exposed to progressively higher simulated altitudes and completed two HH submaximal exercise sessions (~30\u2009min ea., \u226572\u2009h apart) on a cycle ergometer at the first altitude that posed a significant challenge to them. Altitude was dependent on individual response as determined from heart rate (HR), peripheral oxygenation (SpO<jats:sub>2<\/jats:sub>), and the ratio of HR response to SpO<jats:sub>2<\/jats:sub> (HR\/SpO<jats:sub>2<\/jats:sub>). Statistical analyses included paired samples <jats:italic>t<\/jats:italic>\u2010test (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05). No significant change in SpO<jats:sub>2<\/jats:sub> (HH\u20101: 85\u2009\u00b1\u20094% vs. HH\u20102: 85\u2009\u00b1\u20094%, <jats:italic>p<\/jats:italic>\u2009=\u20090.684) was observed between sessions. However, there were significant decreases in: HR (HH\u20101: 150\u2009\u00b1\u200918\u2009bpm vs. HH\u20102: 133\u2009\u00b1\u200927\u2009bpm, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) of 18\u2009bpm (11%); HR\/SpO<jats:sub>2<\/jats:sub> (HH\u20101: 1.76\u2009\u00b1\u20090.22 vs. HH\u20102: 1.57\u2009\u00b1\u20090.33, <jats:italic>p<\/jats:italic>\u2009=\u20090.012); and RPE (HH\u20101: 15\u2009\u00b1\u20092 vs. HH\u20102: 11\u2009\u00b1\u20094, <jats:italic>p<\/jats:italic>\u2009=\u20090.017). While workload significantly increased (HH\u20101: 89\u2009\u00b1\u200936\u2009W vs. HH\u20102: 105\u2009\u00b1\u200936\u2009W, <jats:italic>p<\/jats:italic>\u2009=\u20090.024). Some participants had a threshold\/challenging altitude, but from a single bout there is evidence of improved tolerance that can last over a week. Further investigation is required to replicate and understand possible mechanisms.<\/jats:p>","DOI":"10.14814\/phy2.70195","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T08:15:56Z","timestamp":1744359356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evidence for sustained physiological adaptation between consecutive exercise bouts at simulated altitude"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3189-847X","authenticated-orcid":false,"given":"Kelsey E.","family":"Joyce","sequence":"first","affiliation":[{"name":"Human Integrative and Environmental Physiology Laboratory Department of Cardiovascular Diseases, Mayo Clinic  Scottsdale Arizona USA"},{"name":"School of Sport, Exercise and Rehabilitation Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Travis","family":"Byrd","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Rehabilitation Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney M.","family":"Wheatley\u2010Guy","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Rehabilitation Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse C.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Rehabilitation Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan K.","family":"Parks","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Rehabilitation Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Johnson","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Rehabilitation Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"ACSM's guidelines for exercise testing and prescription","author":"American College of Sports Medicine","year":"2018"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs20030161"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101960\u20103407"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1982.126.5.825"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2008.10.012"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2019.33.1_supplement.843.13"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01019.2004"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u2010201X.2001.00906.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32832c0018"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.272.3.H1157"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24941"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4048543"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1156"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011\u20102829"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2012.08.009"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00\u20100703com"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00375"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.6.H2000"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jp270651"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4498"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279\u2010013\u20100017\u20101"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370216657614"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wem.2014.06.011"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2009"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968311412055"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01284.2005"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2017.0032"},{"key":"e_1_2_11_30_1","volume-title":"Altitude training and athletic performance","author":"Wilber R. 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