{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:12:37Z","timestamp":1753884757854,"version":"3.41.2"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011727","name":"Stockholm l\u00e4ns landsting","doi-asserted-by":"publisher","award":["2020","2021"],"award-info":[{"award-number":["2020","2021"]}],"id":[{"id":"10.13039\/501100011727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Maximal oxygen uptake (VO<jats:sub>2<\/jats:sub>max) in healthy subjects is primarily limited by systemic oxygen delivery. In chronic kidney disease (CKD), VO<jats:sub>2<\/jats:sub>max is potentially reduced by both central and peripheral factors. We aimed to investigate the effect on VO<jats:sub>2<\/jats:sub>peak of adding arm exercise to leg exercise. Ten individuals with CKD stages 3\u20135 and 10 healthy controls, matched for age, sex, body size, and physical activity level, were included. Subjects performed two maximal exercise tests, one with legs only (L exercise) and one test where arm exercise was added to leg exercise (LA exercise). The increase in VO<jats:sub>2<\/jats:sub>peak, when comparing LA exercise with L exercise, was significantly higher in CKD (0.20\u2009\u00b1\u20090.18\u2009L\/min or 2.31\u2009\u00b1\u20091.78\u2009mL\/(kg\u00b7min)) than in controls (0.019\u2009\u00b1\u20090.12\u2009L\/min or 0.26\u2009\u00b1\u20091.62\u2009mL\/(kg\u00b7min); <jats:italic>p<\/jats:italic>\u2009=\u20090.02 and 0.01, respectively). The decrease in peak leg workload, when comparing L exercise with LA exercise, was larger in controls than in CKD, in absolute terms (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) and relative to body weight (<jats:italic>p<\/jats:italic>\u2009=\u20090.01). VO<jats:sub>2<\/jats:sub>max in individuals with CKD is dependent on the active muscle mass, supporting a peripheral limitation to VO<jats:sub>2<\/jats:sub>max in CKD. By contrast, the control group appeared to have a more central limitation to VO<jats:sub>2<\/jats:sub>max.<\/jats:p>","DOI":"10.14814\/phy2.70200","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T04:19:44Z","timestamp":1736914784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exercise limitation in chronic kidney disease: An experimental pilot study with leg and arm exercise"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9187-2426","authenticated-orcid":false,"given":"Helena","family":"Wallin","sequence":"first","affiliation":[{"name":"Division of Clinical Physiology Department of Laboratory Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Clinical Physiology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Jansson","sequence":"additional","affiliation":[{"name":"Division of Clinical Physiology Department of Laboratory Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Clinical Physiology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragad","family":"Said","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-5200","authenticated-orcid":false,"given":"Sigrid","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Nephrology Clinic Danderyds Hospital  Stockholm Sweden"},{"name":"Department of Clinical Science Danderyds Hospital, Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pourya","family":"Zolfaghardidani","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset, Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J.","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anette","family":"Rickenlund","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6361-8965","authenticated-orcid":false,"given":"Patrik","family":"Sundblad","sequence":"additional","affiliation":[{"name":"Division of Clinical Physiology Department of Laboratory Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Clinical Physiology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1961.16.6.977"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200001000-00012"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1179\/1351000214Y.0000000114"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1976.41.2.191"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0790239"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020091319"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx064"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12706"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90771-X"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80563-4"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-184"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12780"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10320819"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ptsp.2014.04.002"},{"issue":"2","key":"e_1_2_12_17_1","first-page":"104","article-title":"The effect on Vo2 max of adding arm work to maximal leg work","volume":"6","author":"Gleser M. A.","year":"1974","journal-title":"Medicine and Science in Sports"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm9708605"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-012-0681-8"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2014.07.005"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10261013"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.5.1351"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.133289"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.135"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.147629"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00556.2011"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12371213"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.06.021"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118646"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199301000-00004"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)70319-0"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000143743.78092.E3"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000183632"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2014.10.013"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00013.2019"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqad013"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm634"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.05.011"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1974.54.1.75"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1867"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg325"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.280.4.R1240"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.38.6.1104"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1977.tb05952.x"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1974.36.5.515"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00411.x"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00380.2018"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1967.22.1.61"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015091034"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw303"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209325"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:05:54Z","timestamp":1748351154000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.70200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.14814\/phy2.70200"],"URL":"https:\/\/doi.org\/10.14814\/phy2.70200","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"type":"print","value":"2051-817X"},{"type":"electronic","value":"2051-817X"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70200"}}