{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:56:33Z","timestamp":1755222993704,"version":"3.43.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T00:00:00Z","timestamp":1739059200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16J07109"],"award-info":[{"award-number":["16J07109"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study determined the relationship between inter\u2010individual variation in arterial O<jats:sub>2<\/jats:sub> saturation (SpO<jats:sub>2<\/jats:sub>) and exercise\u2010induced endocrine and angiogenic growth factor responses under hypoxia. Sixteen healthy men completed two trials on separate days: 60\u2009min of cycling at 65% of maximal oxygen uptake (VO<jats:sub>2<\/jats:sub>max) followed by a 60\u2010min rest period, under either normoxia (FiO<jats:sub>2<\/jats:sub>\u2009=\u200920.9%, NOR) or hypoxia (FiO<jats:sub>2<\/jats:sub>\u2009=\u200914.5%, HYP). Serum growth hormone (GH), cortisol, and vascular endothelial growth factor (VEGF) concentrations were determined before, immediately after, and at 60\u2009min after exercise. SpO<jats:sub>2<\/jats:sub> and heart rate were continuously measured during exercise. In the HYP trial, the average SpO<jats:sub>2<\/jats:sub> during exercise varied by &gt;10% among all participants (77.5%\u201388.2%). However, the \u0394SpO<jats:sub>2<\/jats:sub> (\u0394\u2009=\u2009HYP\u2013NOR) did not correlate significantly with exercise\u2010induced changes in serum \u0394GH (<jats:italic>r<\/jats:italic>\u2009=\u20090.205, <jats:italic>p<\/jats:italic>\u2009=\u20090.446), \u0394cortisol (<jats:italic>r<\/jats:italic>\u2009=\u20090.059, <jats:italic>p<\/jats:italic>\u2009=\u20090.828), and \u0394VEGF (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.004, <jats:italic>p<\/jats:italic>\u2009=\u20090.989). Moreover, no significant correlations were observed between the absolute SpO<jats:sub>2<\/jats:sub> value and exercise\u2010induced responses in these blood variables in the HYP trial. Inter\u2010individual variation in SpO<jats:sub>2<\/jats:sub> did not modify exercise\u2010induced endocrine (GH, cortisol) or angiogenic growth factor (VEGF) responses to endurance exercise in hypoxia.<\/jats:p>","DOI":"10.14814\/phy2.70221","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T20:24:58Z","timestamp":1739219098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inter\u2010individual variation in <scp>SpO<sub>2<\/sub><\/scp> during endurance exercise in hypoxia does not correlate with endocrine and angiogenic growth factor responses"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5648-7899","authenticated-orcid":false,"given":"Hisashi","family":"Mori","sequence":"first","affiliation":[{"name":"School of Human Science and Environment University of Hyogo  Himeji Hyogo Japan"},{"name":"Faculty of Sport and Health Science Ritsumeikan University  Kusatsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyejung","family":"Hwang","sequence":"additional","affiliation":[{"name":"Faculty of Sport and Health Science Ritsumeikan University  Kusatsu Shiga Japan"},{"name":"Physical Activity and Performance Institute Konkuk University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9911-3229","authenticated-orcid":false,"given":"Kazushige","family":"Goto","sequence":"additional","affiliation":[{"name":"Faculty of Sport and Health Science Ritsumeikan University  Kusatsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100838.2009.00985.x"},{"issue":"2","key":"e_1_2_11_3_1","first-page":"90","article-title":"Perceived exertion: A note on \"history\" and methods","volume":"5","author":"Borg G. 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