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Currently, there is no proven dietary approach to support asphyxiated newborns. This study investigates whether oral plasma supplementation improves kidney function and overall health in asphyxiated newborns. Cesarean\u2010delivered near\u2010term pigs with or without an 8\u2009min intrauterine clamping of the umbilical cord were fed a milk replacer dissolved in water for 24\u2009h in Experiment 1. Pigs were fed 72\u2009h with milk replacers dissolved in either maternal plasma or water in Experiment 2. Blood, urine, and kidney tissue were collected for further analyses. Asphyxia disrupted blood electrolyte balance. And plasma feeding led to higher fluid retention for both asphyxiated and control pigs. Additionally, plasma feeding may also affect kidney development and protect kidneys from asphyxia induced impairments. Birth asphyxia in pigs led to immediate disturbance of electrolyte balance, impaired fluid retention, and kidney impairments. Plasma feeding may improve postnatal newborn hydration and may also improve the condition of kidneys following asphyxia.<\/jats:p>","DOI":"10.14814\/phy2.70238","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:24:16Z","timestamp":1738801456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postnatal enteral plasma supplementation following birth asphyxia increases fluid retention and kidney health in newborn pigs"],"prefix":"10.14814","volume":"13","author":[{"given":"Jingren","family":"Zhong","sequence":"first","affiliation":[{"name":"Section for Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences University of Copenhagen  Frederiksberg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislava","family":"Pankratova","sequence":"additional","affiliation":[{"name":"Section for Comparative Pediatrics and Nutrition, 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