{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:22:24Z","timestamp":1790292144014,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102020\u201006269"],"award-info":[{"award-number":["RGPIN\u20102020\u201006269"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102020\u201005760"],"award-info":[{"award-number":["RGPIN\u20102020\u201005760"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyperthermia is known to induce hypocapnia\u2010driven reductions in cerebral blood flow; however, it is unknown if it causes changes in hemodynamic pulsatility that negatively influence cerebrovascular function. This retrospective analysis aimed to assess cerebrovascular hemodynamic pulsatile buffering (damping factor; DFi) during poikilocapnic (HT) and isocapnic (HT\u2010C) hyperthermia. We hypothesized that HT would reduce cerebral DFi, while HT\u2010C would attenuate the reduction in DFi by limiting increases in resistance. Ten healthy males were passively heated +2\u00b0C from normothermia (BL). Blood flow through the internal carotid artery (ICA) and vertebral artery (VA) was measured using vascular ultrasound. Blood velocity through the middle cerebral artery (MCA) and the posterior cerebral artery (PCA) was measured using transcranial ultrasound. DFi was calculated as the ratio of proximal to distal pulsatility index (PI): Anterior cerebral DFi\u2009=\u2009PI<jats:sub>ICA<\/jats:sub>\/PI<jats:sub>MCA<\/jats:sub>; Posterior cerebral DFi\u2009=\u2009PI<jats:sub>VA<\/jats:sub>\/PI<jats:sub>PCA<\/jats:sub>. Anterior DFi decreased in both HT (1.08\u2009\u00b1\u20090.19 a.u; <jats:italic>p<\/jats:italic>\u2009=\u20090.007) and HT\u2010C (1.12\u2009\u00b1\u20090.231 a.u; <jats:italic>p<\/jats:italic>\u2009=\u20090.021) conditions from BL values (1.27\u2009\u00b1\u20090.14 a.u). No changes were observed in posterior DFi, <jats:italic>p<\/jats:italic>\u2009=\u20090.116. Irrespective of P<jats:sub>a<\/jats:sub>CO<jats:sub>2<\/jats:sub> clamping, both hyperthermic conditions reduced anterior DFi, suggesting other mechanisms are responsible for cerebrovascular hemodynamic buffering. Posterior DFi responses were not observed, suggesting preferential buffering of the hyperthermic posterior circulation (VA\u2013PCA).<\/jats:p>","DOI":"10.14814\/phy2.70258","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:17:30Z","timestamp":1741742250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Regional cerebral pulsatile hemodynamics during isocapnic and poikilocapnic hyperthermia in young men"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8799-230X","authenticated-orcid":false,"given":"Spencer J.","family":"Skaper","sequence":"first","affiliation":[{"name":"Cerebrovascular Health Exercise and Environmental Research Sciences (CHEERS) Laboratory, Department of Exercise Science, Physical &amp; Health Education University of Victoria  Victoria British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke R.","family":"Shepley","sequence":"additional","affiliation":[{"name":"Faculty of Human Kinetics University of Windsor  Windsor Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim Amr","family":"Wafai","sequence":"additional","affiliation":[{"name":"Faculty of Human Kinetics University of Windsor  Windsor Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N.","family":"Ainslie","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung and Vascular Health, School of Health and Exercise Science University of British Columbia \u2013 Okanagan  Kelowna British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony R.","family":"Bain","sequence":"additional","affiliation":[{"name":"Faculty of Human Kinetics University of Windsor  Windsor Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Cerebrovascular Health Exercise and Environmental Research Sciences (CHEERS) Laboratory, Department of Exercise Science, Physical &amp; Health Education University of Victoria  Victoria British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102019\u2010031825"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00926.2020"},{"key":"e_1_2_11_4_1","unstructured":"Ashton K.(2013).The effect of passive heat stress on arterial wave reflection pulse wave velocity and cerebral blood flow. 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