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We will examine what is known about external EVs from dietary and bacterial sources and the immense anti\u2010inflammatory, immune\u2010modulatory, and proliferative potential within these nano\u2010sized information carriers. EV interactions with the intestinal and colonic epithelium and associated immune cells at homeostatic and disease states, such as necrotizing enterocolitis (NEC) and inflammatory bowel disease (IBD) will also be covered. 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