{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:24:36Z","timestamp":1783013076755,"version":"3.54.6"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In individuals with spinal cord injury (SCI) and neurogenic bladder dysfunction, guidelines recommend regular monitoring of kidney function by measuring the glomerular filtration rate using an externally administered filtration markers such as 99mTc\u2010DTPA, since creatinine\u2010based eGFR models are inaccurate due to lower muscle mass in these individuals. To examine the feasibility of substituting GFR measurements with eGFR based on s\u2010cystatin C, simultaneous 99mTc\u2010DTPA clearance (mGFR) and cystatin C\u2010based clearance (eGFRcys) measures were evaluated in 248 individuals with SCI. In a subgroup of 26 participants, the test\u2013retest variability of eGFRcys was assessed. Finally, long\u2010term (1\u20133\u2009years) repeatability of simultaneously measured mGFR and eGFRcys was evaluated in 40 individuals. We could demonstrate a very good correlation between mGFR and eGFRcys, with an intraclass correlation (ICC) of 0.92, a very good test\u2013retest variation of eGFRcys (ICC: 0.98) and a very good long\u2010term repeatability of eGFRcys and mGFR (ICC 0.92 and 0.94, respectively). We conclude that in individuals with SCI, eGFR calculated from a single sample of cystatin C can replace measurements of GFR using an externally administered substance. Using a fixed normal limit rather than an age\u2010corrected normal material for p\u2010cystatin C or eGFRCYS will misclassify many individuals as having chronic kidney disease.<\/jats:p>","DOI":"10.14814\/phy2.70315","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T02:14:46Z","timestamp":1747102486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Feasibility of replacing\n                    <scp>\n                      <sup>99m<\/sup>\n                      Tc\n                    <\/scp>\n                    \u2010\n                    <scp>DTPA GFR<\/scp>\n                    measurements with\n                    <scp>eGFR<\/scp>\n                    from cystatin C in individuals with spinal cord injuries"],"prefix":"10.14814","volume":"13","author":[{"given":"Tatiana","family":"Kristensen","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital \u2010 Rigshospitalet; 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Glostrup  Copenhagen Denmark"},{"name":"Institute of Clinical Medicine, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2214-0496","authenticated-orcid":false,"given":"Ulrik B.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital \u2010 Rigshospitalet; Glostrup  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07457.x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/096228029900800204"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365597709179963"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365517609068016"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs265"},{"issue":"5","key":"e_1_2_13_7_1","first-page":"303","article-title":"A formula to estimate the approximate surface area if height and weight be known. 1916","volume":"5","author":"Du Bois D.","year":"1989","journal-title":"Nutrition"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2015.242"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2012.52"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2010.486441"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002239"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41393-017-0045-z"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1981.tb00909.x"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2301-z"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2010.491124"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2102953"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114248"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000054774"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-4-200608150-00004"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.729"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11271210"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.07.027"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP74132"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/38.10.1933"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30279-2"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.03.027"},{"issue":"6","key":"e_1_2_13_30_1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/joneph\/21.6.797","article-title":"Evaluating the performance of equations for estimating glomerular filtration rate","volume":"21","author":"Stevens L. 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