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The purpose of this study is to determine whether Prader\u2010Willi Syndrome (PWS), a genetic cause for obesity (OB), or non\u2010syndromic OB influences these cytokine responses to RE. Nine children with PWS (11.4\u2009\u00b1\u20093.3\u2009years, 45.6\u2009\u00b1\u20095.2% BF), 11 children without OB (9.2\u2009\u00b1\u20091.4\u2009years, 18.6\u2009\u00b1\u20095.0% BF), and 12 children with OB (9.6\u2009\u00b1\u20091.3\u2009years, 40.4\u2009\u00b1\u20095.4% BF) participated. Children stepped onto an elevated platform wearing a weighted vest for 6 sets of 10 repetitions per leg separated by 1\u2009min of rest. Blood samples were obtained before exercise (pre), immediately post (IP), and during recovery (+15 and +60\u2009min). There were no group\u2010by\u2010time interactions for any cytokine; and neither time nor group effects for TNF\u2010\u03b1 or irisin (<jats:italic>p<\/jats:italic>\u2009\u2265\u20090.378). For IL\u20106, 60+ was higher than pre, IP, and +15 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Children with PWS and OB had increased IL\u20106 than children without OB (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.038). Neither PWS nor OB affected IL\u20106, TNF\u2010\u03b1 or irisin responses to RE. However, excess body fat was associated with higher IL\u20106 concentrations.<\/jats:p>","DOI":"10.14814\/phy2.70327","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T10:57:08Z","timestamp":1744887428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cytokine response to resistance exercise in children with excess adiposity and Prader\u2010Willi syndrome"],"prefix":"10.14814","volume":"13","author":[{"given":"Vincent","family":"Vuong","sequence":"first","affiliation":[{"name":"Department of Kinesiology California State University Fullerton  Fullerton California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Haqq","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta Canada"},{"name":"Department of Agricultural, Food &amp; Nutritional Science University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1578-8251","authenticated-orcid":false,"given":"Daniela A.","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Kinesiology California State University Fullerton  Fullerton California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"s176","article-title":"Obesity: Definition, comorbidities, causes, and burden","volume":"22","author":"Apovian C. 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