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Myocardial bridging (MB) may impact coronary microvascular function, but its effect on the relationship between RHI and coronary microvascular function remains unclear. In this cross\u2010sectional study, 38 patients underwent noninvasive RHI assessment alongside invasive coronary microvascular function testing. MB was identified via coronary angiography, while endothelium\u2010dependent and independent coronary microvascular function were evaluated using coronary flow reserve in response to intracoronary administration of acetylcholine and microvascular resistance reserve in response to intravenous administration of adenosine, respectively. Among 38 patients (mean age: 59\u2009years, 34% male), 14 had MB. RHI correlated with an index of endothelium\u2010independent coronary microvascular function (<jats:italic>r<\/jats:italic>\u2009=\u20090.34, <jats:italic>p<\/jats:italic>\u2009=\u20090.04), whereas it did not correlate with that of endothelium\u2010dependent function. This correlation persisted in patients without MB (<jats:italic>r<\/jats:italic>\u2009=\u20090.54, <jats:italic>p<\/jats:italic>\u2009=\u20090.01) but was lost in those with MB (<jats:italic>p<\/jats:italic>\u2009=\u20090.83). RHI is associated with endothelium\u2010independent coronary microvascular function, but MB disrupts this relationship, suggesting a local impact on coronary microvascular physiology.<\/jats:p>","DOI":"10.14814\/phy2.70340","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:35:07Z","timestamp":1745465707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between peripheral and coronary microvascular function and the impact of myocardial bridging"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4681-2798","authenticated-orcid":false,"given":"Takumi","family":"Toya","sequence":"first","affiliation":[{"name":"Division of Cardiology National Defense Medical College  Saitama Japan"},{"name":"Department of Cardiology NHO Tokyo Medical Center  Tokyo 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