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While sit\u2010stand maneuvers (SSM) have been used to assess baroreflex sensitivity (BRS), they may be impractical for physically immobile individuals. This study examined cardiac BRS during repeated handgrip exercise (RHE) compared to SSM and spontaneous rest. Twenty participants (10 females) performed 5\u2010min RHE and SSM at 0.10 and 0.05\u2009Hz in random order after spontaneous rest. Cardiac BRS was calculated using transfer function analysis (BRS\n                    <jats:sub>TFA<\/jats:sub>\n                    ) and the sequence method (BRS\n                    <jats:sub>SM<\/jats:sub>\n                    ) in low (LF: 0.05\u20130.15\u2009Hz) and very low (VLF: 0.02\u20130.07\u2009Hz) frequencies. Power spectral density (PSD) quantified systolic blood pressure (SBP) and R\u2010R interval (RRI) oscillations. Compared to rest, 0.10 and 0.05\u2009Hz RHE significantly increased SBP and RRI PSDs, with the highest values observed during SSM in both frequencies. RHE significantly increased LF and VLF BRS\n                    <jats:sub>TFA<\/jats:sub>\n                    coherence by 132% and 142%, while SSM increased them by 144% and 209%. Regardless of analytical methods, BRS remained unchanged during RHE compared to rest, but it significantly decreased during 0.10\u2009Hz SSM, which correlated with increased heart rate. These findings suggest that RHE improves BRS\n                    <jats:sub>TFA<\/jats:sub>\n                    estimation via increased coherence, whereas reduced BRS during SSM suggests baroreflex resetting.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70352","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T10:02:57Z","timestamp":1746439377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac baroreflex sensitivity during repeated handgrip exercise: Comparisons with sit\u2010stand maneuvers and spontaneous rest"],"prefix":"10.14814","volume":"13","author":[{"given":"Wenxing","family":"Qin","sequence":"first","affiliation":[{"name":"Institute of Health and Sport Sciences University of Tsukuba  Tsukuba Ibaraki Japan"},{"name":"Human Informatics and Interaction Research Institute National Institute of Advanced Industrial Science and Technology  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Fukuie","sequence":"additional","affiliation":[{"name":"Human Informatics and Interaction Research Institute National Institute of Advanced Industrial Science and Technology  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Human Informatics and Interaction Research Institute National Institute of Advanced Industrial Science and Technology  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoya","family":"Mori","sequence":"additional","affiliation":[{"name":"Institute of Health and Sport Sciences University of Tsukuba  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsubasa","family":"Tomoto","sequence":"additional","affiliation":[{"name":"Human Informatics and Interaction Research Institute National Institute of Advanced Industrial Science and Technology  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5297-6468","authenticated-orcid":false,"given":"Shigehiko","family":"Ogoh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Toyo University  Saitama Japan"},{"name":"Neurovascular Research Laboratory University of South Wales  Pontypridd UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Institute of Health and Sport Sciences University of Tsukuba  Tsukuba Ibaraki Japan"},{"name":"Human Informatics and Interaction Research Institute National Institute of Advanced Industrial Science and Technology  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7061-8867","authenticated-orcid":false,"given":"Takashi","family":"Tarumi","sequence":"additional","affiliation":[{"name":"Institute of Health and Sport Sciences University of Tsukuba  Tsukuba Ibaraki Japan"},{"name":"Human Informatics and Interaction Research Institute National Institute of Advanced Industrial Science and Technology  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00402.2012"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1937.sp003485"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1938.sp003592"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13246-023-01380-y"},{"key":"e_1_2_12_6_1","unstructured":"Blomqvist C. 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