{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:24:43Z","timestamp":1783013083229,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009193","name":"Marsden Fund","doi-asserted-by":"publisher","award":["19\u2010UOA\u2010170"],"award-info":[{"award-number":["19\u2010UOA\u2010170"]}],"id":[{"id":"10.13039\/501100009193","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Aerobic exercise reduces the risk of cerebrovascular dysfunction. One proposed mechanism is exercise\u2010induced increases in cerebral shear stress (SS) improving cerebral endothelial function. A recent report indicated that interval exercise (Int\u2010Ex) induces greater cerebral SS than continuous exercise (Con\u2010Ex); however, its effect on cerebral endothelial function remains unclear. We hypothesized that Int\u2010Ex would enhance cerebral SS and, consequently, cerebral endothelial function more than Con\u2010Ex. Fourteen healthy males (21\u2009\u00b1\u20090.6\u2009years) completed 32\u2009min of Int\u2010Ex and work\u2010equivalent Con\u2010Ex on a semi\u2010recumbent bike on separate days. Cerebrovascular flow\u2010mediated dilatation (cFMD) was assessed before exercise (Pre), 15\u2009min (Post\u201015) and 40\u2009min post\u2010exercise (Post\u201040). cFMD was defined as peak internal carotid artery vasodilatation (\u0394% from baseline; Duplex ultrasound) in response to a 30\u2010s hypercapnic exposure, raising end\u2010tidal partial pressure of carbon dioxide by ~7\u2009mmHg. Post\u2010exercise cerebral SS was greater after Int\u2010Ex versus Con\u2010Ex (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002). Int\u2010Ex evoked a ~37% increase in post\u2010exercise cerebral SS compared to rest, with a negligible increase for Con\u2010Ex. cFMD did not differ between Int\u2010Ex and Con\u2010Ex trials before exercise (Pre, 6.35\u2009\u00b1\u20093.89% vs. 5.54\u2009\u00b1\u20093.83%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.542) and remained unchanged post\u2010exercise (Post\u201015, 7.20\u2009\u00b1\u20094.47% vs. 6.13\u2009\u00b1\u20094.08%; Post\u201040, 5.69\u2009\u00b1\u20093.86% vs. 6.94\u2009\u00b1\u20093.55%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.583). These results indicate that Int\u2010Ex and Con\u2010Ex have similar acute effects on cerebral endothelial function.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70354","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T09:50:10Z","timestamp":1746438610000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of interval versus continuous exercise on cerebral vascular flow\u2010mediated dilatation in young healthy males"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0348-5597","authenticated-orcid":false,"given":"Harvey J.","family":"Walsh","sequence":"first","affiliation":[{"name":"Department of Physiology Faculty of Medical &amp; Health Sciences, University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-0091","authenticated-orcid":false,"given":"Shotaro","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Toyo University  Kawagoe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narumi","family":"Kunimatsu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Toyo University  Kawagoe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marino","family":"Karaki","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Toyo University  Kawagoe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medical &amp; Health Sciences, University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5297-6468","authenticated-orcid":false,"given":"Shigehiko","family":"Ogoh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Toyo University  Kawagoe Japan"},{"name":"Neurovascular Research Laboratory University of South Wales  Pontypridd UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.158279"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00224"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270946"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100032\u20101323829"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20957807"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1397"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00450.2013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.12.1351"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00045.2006"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP282707"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00119.2017"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.179432"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001924"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00333"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14430"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100035\u20101555115"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14705"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.201900069"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010020\u201006752\u20106"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP091125"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00543.2023"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421\u2010021\u201004721\u20105"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.609935"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00484.2021"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.13796"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.70354","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:02:10Z","timestamp":1783011730000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.70354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.14814\/phy2.70354"],"URL":"https:\/\/doi.org\/10.14814\/phy2.70354","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70354"}}