{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:34:52Z","timestamp":1791376492221,"version":"4.3.2"},"reference-count":41,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DKDK125794"],"award-info":[{"award-number":["R01 DKDK125794"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK101509"],"award-info":[{"award-number":["R01 DK101509"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R01HL155523"],"award-info":[{"award-number":["1R01HL155523"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R01HL157378"],"award-info":[{"award-number":["1R01HL157378"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1\u2010TR000445"],"award-info":[{"award-number":["UL1\u2010TR000445"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["5I01CX001755"],"award-info":[{"award-number":["5I01CX001755"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sarcopenia is common in advanced chronic kidney disease (CKD), contributing to poor outcomes. Intermuscular adipose tissue (IMAT) may worsen muscle function through metabolic and inflammatory pathways. We conducted a cross\u2010sectional study comparing maintenance hemodialysis (MHD) patients and controls to assess IMAT and its associations. IMAT was measured via calf muscle MRI, and body composition (BMI, fat mass index), metabolic markers (hs\u2010CRP, TNF\u2010\u03b1, IL\u20106, insulin resistance), and circulating cell\u2010free mitochondrial DNA (ccf\u2010mtDNA) were assessed. Muscle function was evaluated with handgrip strength. IMAT differences between groups were tested using inverse propensity weighting. We analyzed 25 MHD patients and 23 controls. Median age was 53\u2009years, BMI 30.4\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , 83% were male, and 56% were African American. Baseline characteristics were similar between groups, except for race. MHD patients had higher IMAT (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and elevated TNF\u2010\u03b1, IL\u20106, and hs\u2010CRP (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). IMAT was positively correlated with IL\u20106 in MHD patients and with TNF\u2010\u03b1 in controls. Handgrip strength was inversely correlated with IMAT in the full cohort (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Our findings highlight the role of IMAT in inflammation and functional decline in CKD, suggesting its potential as a therapeutic target.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70363","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T06:54:36Z","timestamp":1752130476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intermuscular adipose tissue and muscle function in patients on maintenance hemodialysis"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0730-7641","authenticated-orcid":false,"given":"R. Gulsah","family":"Dilaver","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Nephrology and Hypertension Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mert","family":"Demirci","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology and Hypertension Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachelle","family":"Crescenzi","sequence":"additional","affiliation":[{"name":"Department of Radiology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pridmore","sequence":"additional","affiliation":[{"name":"Department of Radiology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lale A.","family":"Ertuglu","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-2424","authenticated-orcid":false,"given":"Andrew","family":"Guide","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Greevy","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baback","family":"Roshanravan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology University of California  Davis, Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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