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These changes make older adults more susceptible to infections, including COVID\u201019, and contribute to worse clinical outcomes, such as higher morbidity and mortality rates. This review explores immunological changes associated with aging, including impaired innate immune responses, reduced T\u2010 and B\u2010cell function, and altered cytokine profiles. A comprehensive literature search identified relevant studies on the topic, and inclusion criteria focused on studies addressing age\u2010related immune changes and their impact on responses to COVID\u201019. The findings underscore the need for targeted healthcare strategies to mitigate the negative effects of aging on immunity and improve immune resilience, and ultimately clinical outcomes and quality of life for this vulnerable population.<\/jats:p>","DOI":"10.14814\/phy2.70364","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T02:33:07Z","timestamp":1747967587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Aging\u2010associated changes in immunological parameters: Implications for COVID\u201019 immune response in the elderly"],"prefix":"10.14814","volume":"13","author":[{"given":"Maha","family":"Gasmi","sequence":"first","affiliation":[{"name":"Higher Institute of Sport and Physical Education of Ksar Said  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi","family":"Hejazi","sequence":"additional","affiliation":[{"name":"Department of 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