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BDNF increases after exercise, but the response may vary with exercise intensity and across blood fractions. While sAPP\u03b1 rises post\u2010exercise in animals, its response to aerobic exercise in humans is unclear. This study examined how BDNF and sAPP\u03b1 respond to moderate and high\u2010intensity exercise in healthy young adult humans. Participants completed three exercise conditions: moderate (65% Watt maximum, 30\u2009min), clinical\u2010HIIT (4\u2009\u00d7\u20094\u2009min, 90% Watt maximum), and all\u2010out\u2010HIIT (8\u2009\u00d7\u200930\u2009s, 150% Watt maximum). Blood\u2010based biomarkers were extracted from venous blood drawn from venepuncture at baseline, immediately after exercise, and after 30\u2009min rest. BDNF concentration was measured in serum, plasma, platelet\u2010poor plasma, and platelets; sAPP\u03b1 in serum via ELISAs. Data were primarily analyzed using mixed effects models. BDNF increased in plasma and platelet\u2010poor plasma across conditions but rose in serum only after clinical\u2010HIIT and moderate intensity exercise. BDNF concentration in platelets was unaffected. sAPP\u03b1 increased after moderate and clinical\u2010HIIT sessions. Measurement of BDNF in serum alone may not fully represent the changes in BDNF post\u2010exercise. Further research is required in adults at risk of AD.<\/jats:p>","DOI":"10.14814\/phy2.70366","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T02:25:18Z","timestamp":1747967118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Brain derived neurotrophic factor and secreted amyloid precursor protein\u2010\u03b1 response to moderate and high intensity exercise"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3063-8147","authenticated-orcid":false,"given":"Felicity S. 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