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Systemic platelet cyclooxygenase inhibition with low\u2010dose ASA attenuates reflex cutaneous vasodilation and accelerates the rate of rise of core temperature during passive heating in middle\u2010aged adults. The functional effect of low\u2010dose ASA therapy on thermoregulatory and cardiovascular responses to hot and humid environmental extremes in older (&gt;65\u2009years) adults has not been determined. Eleven older adults (5F; 66\u201380\u2009years) were exposed to progressive heat stress in an environmental chamber at a metabolic rate comparable to activities of daily living (~80\u2009W\u2219m\n                    <jats:sup>\u22122<\/jats:sup>\n                    ) in a warm\u2010humid (WH; 36\u00b0C, 52% rh) and hot\u2010dry (HD; 40\u00b0C, 21% rh) environment following 7\u2009days of low\u2010dose ASA (81\u2009mg\/day) or placebo. Core temperature (T\n                    <jats:sub>c<\/jats:sub>\n                    ), skin temperature (T\n                    <jats:sub>sk<\/jats:sub>\n                    ), heart rate (HR), mean arterial pressure (MAP) and forearm blood flow (FBF) were measured, and rate\u2010pressure product was subsequently calculated. Low\u2010dose ASA attenuated FBF and forearm vascular conductance (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.04) but had no effect on T\n                    <jats:sub>c<\/jats:sub>\n                    or T\n                    <jats:sub>sk<\/jats:sub>\n                    in either environment. In conclusion, low\u2010dose ASA attenuates the skin blood flow response during minimal activity heat stress in both dry and humid environments but does not alter T\n                    <jats:sub>c<\/jats:sub>\n                    .\n                  <\/jats:p>","DOI":"10.14814\/phy2.70375","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T02:55:41Z","timestamp":1747018541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low\u2010dose\n                    <scp>ASA<\/scp>\n                    therapy does not alter core or skin temperature during hot\u2010dry or warm\u2010humid heat stress (\n                    <scp>PSU HEAT<\/scp>\n                    project)"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5231-1719","authenticated-orcid":false,"given":"Kat G.","family":"Fisher","sequence":"first","affiliation":[{"name":"Center for Healthy Aging Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Department of Kinesiology Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6934-7755","authenticated-orcid":false,"given":"Olivia K.","family":"Leach","sequence":"additional","affiliation":[{"name":"Department of Kinesiology Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6567-9785","authenticated-orcid":false,"given":"Rachel M.","family":"Cottle","sequence":"additional","affiliation":[{"name":"Center for Healthy Aging Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Department of Kinesiology Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1294-8582","authenticated-orcid":false,"given":"Lacy M.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Center for Healthy Aging Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Department of Kinesiology Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Graduate Program in Physiology Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1326-8175","authenticated-orcid":false,"given":"W. Larry","family":"Kenney","sequence":"additional","affiliation":[{"name":"Center for Healthy Aging Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Department of Kinesiology Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Graduate Program in Physiology Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31827981dc"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00191.2018"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.63.2.306"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.186965"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00750.2009"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01362.2009"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91215.2008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/jes.0b013e3180a02f85"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.07.026"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.12.10.1206"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2012.00523.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00691250"},{"key":"e_1_2_10_14_1","volume-title":"ACSM's guidelines for exercise testing and prescription","author":"Liguori G.","year":"2020"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00710.2005"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/23328940.2020.1801119"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19-0953"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(96)00019-8"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.72.6.1177"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.1_suppl.39S"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198411083111902"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1964.19.3.531"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/376721"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1953.sp004926"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.70002"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.70375","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:01:49Z","timestamp":1783011709000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.70375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.14814\/phy2.70375"],"URL":"https:\/\/doi.org\/10.14814\/phy2.70375","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70375"}}