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Fifteen young adults performed SSCs under four stretch activation conditions: passive stretch (ST<jats:sub>0%<\/jats:sub>\u2010SC), feedback\u2010guided active stretch (ST<jats:sub>40%<\/jats:sub>\u2010SC and ST<jats:sub>80%<\/jats:sub>\u2010SC), and maximal effort stretch (ST<jats:sub>100%<\/jats:sub>\u2010SC). All conditions involved maximal voluntary activation during shortening, followed by a fixed\u2010end contraction at 20\u00b0. Outcome measures included joint torque and work, estimated fascicle force and work, vastus lateralis fascicle length and velocity, and quadriceps activation. Compared to passive stretch, active stretch conditions produced greater SSC effects, with no significant differences between ST<jats:sub>80%<\/jats:sub>\u2010SC and ST<jats:sub>100%<\/jats:sub>\u2010SC. Fascicle work did not differ significantly across conditions, suggesting a decoupling between joint\u2010level output and fascicle\u2010level contribution. Active stretch primarily enhanced force production during early shortening; however, the SSC effect persisted until mid\u2010to\u2010late shortening (80\u00b0 to 38\u00b0) in ST<jats:sub>80%<\/jats:sub>\u2010SC. ST<jats:sub>0%<\/jats:sub>\u2010SC also showed nearly twice the fascicle shortening velocity of other conditions. Following shortening, ST<jats:sub>100%<\/jats:sub>\u2010SC exhibited greater residual force depression during the isometric phase, despite similar activation. These findings demonstrate that voluntary activation during stretch modulates SSC effect through a complex interplay involving muscle\u2010tendon unit decoupling and history\u2010dependent effects, fascicle dynamics, and tendon compliance.<\/jats:p>","DOI":"10.14814\/phy2.70377","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T02:10:21Z","timestamp":1747361421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modulation of stretch activation influences the stretch\u2010shortening cycle effect in in\u00a0vivo human knee extensors"],"prefix":"10.14814","volume":"13","author":[{"given":"Iseul","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Physical Education, Graduate School Yonsei University  Seoul Korea"},{"name":"Frontier Research Institute of Convergence Sports Science, College of Educational Sciences Yonsei University  Seoul 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