{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:06:22Z","timestamp":1787022382452,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009003","name":"Hotchkiss Brain Institute, University of Calgary","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009408","name":"Fondation Brain Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008459","name":"University of Calgary","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alterations in autonomic cardiovascular function may result following mild traumatic brain injury (mTBI), but there is a lack of data evaluating autonomic function in adults with persisting post\u2010concussive symptoms (PPCS). We collected resting measures of heart rate (HR), heart rate variability (HRV), blood pressure (BP) and cardiac baroreceptor sensitivity in 50 adults with PPCS (42.8 (11.0) years; 24.5 (14.2) months post\u2010injury; 74% female) and 50 age\/sex\u2010matched controls (43.0 (11.1) years; 74% female) with no lifetime mTBI history. HR and BP data were collected for \u22654\u2009min when seated and standing. Between\u2010group differences (PPCS vs. control) were analyzed using linear regression. In the seated posture, participants with PPCS had significantly lower HRV than controls, specifically RMSSD (root mean squared of successive RR interval differences) (mean difference\u2009=\u2009\u221210.450,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) and SDNN (standard deviation of RR intervals) (mean difference\u2009=\u2009\u221212.875,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). In the standing position, PPCS had lower SDNN. Participants with PPCS had significantly lesser change in HRV, including RMSSD (mean difference\u2009=\u20095.981,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007) and LF\/HF (low\u2010frequency to high\u2010frequency ratio) (mean difference\u2009=\u2009\u22122.229,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.016), when going from seated to standing compared to controls. Findings suggest adults with PPCS have altered autonomic function relative to controls. Physical activity level and deconditioning are potential treatment targets to improve autonomic function.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70378","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T08:36:54Z","timestamp":1750149414000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Altered autonomic cardiovascular function in adults with persisting post\u2010concussive symptoms and exercise intolerance"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8367-6572","authenticated-orcid":false,"given":"Leah J.","family":"Mercier","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Physical Medicine and Rehabilitation University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute (HBI), University of Calgary  Calgary Alberta 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Centre (SIPRC), Faculty of Kinesiology University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Esser","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute (HBI), University of Calgary  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute (ACHRI) University of Calgary  Calgary Alberta Canada"},{"name":"Department of Pediatrics, Section of Neurology University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute (HBI), University of Calgary  Calgary Alberta Canada"},{"name":"Sport Injury Prevention Research Centre (SIPRC), Faculty of Kinesiology University of Calgary  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute (ACHRI) University of Calgary  Calgary Alberta 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