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Healthy male rats (<jats:italic>N<\/jats:italic>\u2009=\u200942) were divided into seven groups of six animals each, with groups 1 and 2 being controls, groups 3, 4, and 5 given increasing doses of DFAE (50, 100, and 200\u2009mg\/kg, <jats:italic>b.w.<\/jats:italic>, <jats:italic>p.o<\/jats:italic>.), and groups 6 and 7 were given sulfasalazine (100\u2009mg\/kg, <jats:italic>b.w.<\/jats:italic>, <jats:italic>p.o.<\/jats:italic>) and gallic acid (50\u2009mg\/kg, <jats:italic>b.w.<\/jats:italic>, <jats:italic>p.o.<\/jats:italic>), respectively, during 10\u2009days. In\u00a0vitro, we found that DFAE's IC<jats:sub>50<\/jats:sub> exhibited a significant antioxidant capacity due to its high phenolic content. The in\u00a0vivo studies showed that the pre\u2010treatment with DFAE significantly reduced AA\u2010induced morphological and histopathological alterations of the colonic mucosa. The antioxidant and anti\u2010inflammatory power of DFAE maintained the redox equilibrium and preserved the intracellular mediators' homeostasis. Our data may suggest that dill fruit is a promising candidate for treating ulcerative colitis by controlling oxidative stress and inflammation.<\/jats:p>","DOI":"10.14814\/phy2.70393","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T03:21:13Z","timestamp":1748402473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protective effects of dill fruit against acute acetic acid\u2010induced ulcerative colitis by reducing inflammation and oxidative stress in rats"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6161-9056","authenticated-orcid":false,"given":"Chirine","family":"Brinsi","sequence":"first","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources (LR23ES08) University of Jendouba, Higher Institute of Biotechnology of B\u00e9ja  B\u00e9ja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassin","family":"Khadraoui","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources (LR23ES08) University of Jendouba, Higher Institute of Biotechnology of B\u00e9ja  B\u00e9ja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariem","family":"Mhimdi","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources (LR23ES08) University of Jendouba, Higher Institute of Biotechnology of B\u00e9ja  B\u00e9ja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slimen","family":"Selmi","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources (LR23ES08) University of Jendouba, Higher Institute of Biotechnology of B\u00e9ja  B\u00e9ja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houcem","family":"Sammari","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources (LR23ES08) University of Jendouba, Higher Institute of Biotechnology of B\u00e9ja  B\u00e9ja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saber","family":"Jedidi","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources (LR23ES08) University of Jendouba, Higher Institute of Biotechnology of B\u00e9ja  B\u00e9ja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6974-6973","authenticated-orcid":false,"given":"Houcine","family":"Selmi","sequence":"additional","affiliation":[{"name":"Laboratory of Sylvo\u2010Pastoral Resources University of Jendouba, Institution of Agricultural Research and Higher Education (IRESA), Sylvo\u2010Pastoral Institute of Tabarka  Tabarka Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-1401","authenticated-orcid":false,"given":"Hichem","family":"Sebai","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources (LR23ES08) University of Jendouba, Higher Institute of Biotechnology of B\u00e9ja  B\u00e9ja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27175451"},{"key":"e_1_2_12_3_1","first-page":"121","volume-title":"Methods in enzymology","author":"Aebi H.","year":"1984"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-49"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15204429"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00625-7"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105884"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2009.02.043"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/separations9060152"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14892"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1283-0"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4155\/ppa.15.14"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(95)02014-4"},{"key":"e_1_2_12_14_1","first-page":"3","article-title":"Automatic assay of blood sugar by Trinder's method","volume":"33","author":"Dingeon B.","year":"1975","journal-title":"Annales de Biologie Clinique"},{"key":"e_1_2_12_15_1","first-page":"421","volume-title":"Methods in enzymology","author":"Draper H. 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