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We measured circulating and intrarenal RA(A)S markers in healthy cats (<jats:italic>n<\/jats:italic>\u2009=\u20098) and cats with induced CKD (<jats:italic>n<\/jats:italic>\u2009=\u20096 subjected to unilateral renal ischemia [RI group] and <jats:italic>n<\/jats:italic>\u2009=\u20095 subjected to RI and delayed contralateral nephrectomy [RI\u2010DCN group]). Serum equilibrium concentrations of angiotensin peptides and aldosterone, plasma renin activity, and urinary aldosterone\u2010to\u2010creatinine ratio were evaluated before and after renal injury in CKD cats and at a single timepoint in healthy cats. Renal tissular concentrations of angiotensin peptides and mRNA levels of RA(A)S\u2010related genes were measured in all cats. There was no significant correlation between circulating angiotensin peptide concentrations and their respective renal concentrations. Intrarenal angiotensin I concentrations and <jats:italic>AGT<\/jats:italic> transcript levels were positively correlated, and <jats:italic>ACE<\/jats:italic> transcript levels were negatively correlated with serum creatinine concentration. Circulating RA(A)S markers were not different between healthy and CKD groups, except for serum angiotensin 1\u20135, which was lower in the RI group compared to the healthy group. Intrarenal angiotensin peptide concentrations did not differ among groups. Compared to healthy cats, mRNA levels of <jats:italic>ACE<\/jats:italic>, <jats:italic>AT1R<\/jats:italic>, and <jats:italic>REN<\/jats:italic> were lower, and <jats:italic>AGT<\/jats:italic> levels were higher in one or both CKD group(s).<\/jats:p>","DOI":"10.14814\/phy2.70417","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T17:57:58Z","timestamp":1750874278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Post hoc comparison of the intrarenal and circulating renin\u2010angiotensin(\u2010aldosterone) systems in cats with ischemia\u2010induced chronic kidney disease"],"prefix":"10.14814","volume":"13","author":[{"given":"Jane H. 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