{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:18:26Z","timestamp":1773019106794,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010057","name":"University of Winchester","doi-asserted-by":"publisher","award":["UoA23_22_Faulk"],"award-info":[{"award-number":["UoA23_22_Faulk"]}],"id":[{"id":"10.13039\/100010057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute prolonged sitting increases blood pressure (BP) and arterial stiffness (AS). Both of these may be mitigated via light physical activity (LPA). Whether long COVID (LC), which partly manifests as vascular sequelae, predisposes a heightened sensitivity to sitting or diminished benefits from its interruption is unknown. The aims of this study were to identify whether individuals with LC: (i) exhibit a worse BP\/AS response to uninterrupted sitting and (ii) a diminished mitigation of BP\/AS response to sitting interrupted with LPA, compared to healthy controls. Thirty participants with LC and 15 controls completed 2\u2009h of uninterrupted sitting and sitting interrupted with LPA. Central and peripheral systolic and diastolic BP and carotid\u2010femoral pulse wave velocity (cfPWV) were determined pre and post sitting. Linear mixed\u2010effects models demonstrated no three\u2010way or two\u2010way interactions for any variable. There was a significant main effect of time, with increases in central systolic (MD\u2009=\u20093.37\u2009mmHg, SE\u2009=\u20090.93\u2009mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and central diastolic (MD\u2009=\u20093.00\u2009mmHg, SE\u2009=\u20090.58\u2009mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) BP. cfPWV was not altered in sitting in either group (MD\u2009=\u20090.13\u2009m\/s, SE\u2009=\u20090.09\u2009m\/s,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.170). Uninterrupted sitting increases BP similarly, but AS is unchanged. Interrupting sitting with LPA did not mitigate sitting\u2010induced increase in BP regardless of LC diagnosis.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70452","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:32:28Z","timestamp":1759815148000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of uninterrupted and interrupted sitting on vascular function in adults with long\n                    <scp>COVID<\/scp>"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4821-8509","authenticated-orcid":false,"given":"Nick","family":"Hudson","sequence":"first","affiliation":[{"name":"School of Sport, Health and Community University of Winchester  Winchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Hannah","sequence":"additional","affiliation":[{"name":"School of Sport, Health and Community University of Winchester  Winchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Husted","sequence":"additional","affiliation":[{"name":"School of Psychology University of Winchester  Winchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Fryer","sequence":"additional","affiliation":[{"name":"School of Education and Science University of Gloucestershire  Gloucester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Ryan\u2010Stewart","sequence":"additional","affiliation":[{"name":"Faculty of Education, Humanities and Health Sciences EIT | Te P\u016bkenga  Hawke's Bay New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Rickenbach","sequence":"additional","affiliation":[{"name":"Faculty of Health and Wellbeing University of Winchester  Winchester UK"},{"name":"Park and St Francis Surgery  Eastleigh, Hampshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keeron","family":"Stone","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Research, Innovation and Development (CURIAD), Cardiff School of Sport and Health Sciences Cardiff Metropolitan University  Cardiff UK"},{"name":"National Cardiovascular Research Network  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Faulkner","sequence":"additional","affiliation":[{"name":"Primary Care Research Centre University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279\u2010023\u201001915\u2010z"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2018.12.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/01410768211032850"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117905"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-020-04138-6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031837"},{"key":"e_1_2_10_8_1","first-page":"2591","article-title":"Estimation of central aortic pressure waveform features derived from the brachial cuff volume displacement waveform","volume":"2012","author":"Butlin M.","year":"2012","journal-title":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328363c789"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4065\/84.9.822"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.10.014"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11190"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2017-098963"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-021-00708-z"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14240"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v7.i4.204"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.18433\/jpps31455"},{"key":"e_1_2_10_18_1","volume-title":"Guyton and Hall textbook of medical physiology: Student consult. 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