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Twelve resistance\u2010trained men performed bouts of LL\u2010BFR (30%1RM) and HL\u2010RE (70%1RM), each consisting of four sets of bilateral seated leg extensions taken to momentary task failure with 60\u2009s rest periods. A randomized crossover design was used with time of day matched within\u2010subjects. Upon arrival between 1200 and 1800, 24\u2009h dietary recalls were performed with post\u2010exercise blood samples obtained within 60\u2009s (IP) and 5\u2009min post\u2010exercise (+5\u2009min) via intravenous cannulation. Greater total repetitions (<jats:italic>d<\/jats:italic>\u2009=\u20092.37, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and less volume\u2010load (<jats:italic>d<\/jats:italic>\u2009=\u20092.86, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were performed during LL\u2010BFR. No Condition \u00d7 Time interaction effects were found for any hormonal analyte measured (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Both LL\u2010BFR and HL\u2010RE elevate the potent \u03b2<jats:sub>2<\/jats:sub> adrenergic receptor (\u03b2<jats:sub>2<\/jats:sub>AR) agonist EPI (IP: 1.29\u2009\u00b1\u20090.44 and 1.35\u2009\u00b1\u20090.60\u2009nmol\u00b7L<jats:sup>\u22121<\/jats:sup>, respectively), and the androgenic steroid T (+5\u2009min: 27.4\u2009\u00b1\u200912.9 and 29.0\u2009\u00b1\u200914.3\u2009nmol\u00b7L<jats:sup>\u22121<\/jats:sup>, respectively). Thus, acute skeletal muscle \u03b2<jats:sub>2<\/jats:sub>AR phosphorylation may be comparable between conditions. When lower resistance exercise intensities (e.g., 30% 1RM) are desired, athletes may perform LL\u2010BFR in place of HL\u2010RE and experience no statistical difference in acute endocrine responses.<\/jats:p>","DOI":"10.14814\/phy2.70455","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T12:31:12Z","timestamp":1752064272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Endocrine responses to low\u2010load blood flow restricted and high\u2010load resistance exercise in well\u2010trained males"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9256-8319","authenticated-orcid":false,"given":"Drake A.","family":"Eserhaut","sequence":"first","affiliation":[{"name":"Jayhawk Athletic Performance Laboratory\u2014Wu Tsai Human Performance Alliance University of Kansas  Lawrence Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5502-6131","authenticated-orcid":false,"given":"Joseph M.","family":"DeLeo","sequence":"additional","affiliation":[{"name":"Jayhawk Athletic Performance Laboratory\u2014Wu Tsai Human Performance Alliance University of Kansas  Lawrence Kansas USA"},{"name":"Female Athlete Program\u2014Wu Tsai Human Performance Alliance Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8192-4931","authenticated-orcid":false,"given":"Jessica A.","family":"Provost","sequence":"additional","affiliation":[{"name":"Jayhawk Athletic Performance Laboratory\u2014Wu Tsai Human Performance Alliance University of Kansas  Lawrence Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8171-7684","authenticated-orcid":false,"given":"Andrew C.","family":"Fry","sequence":"additional","affiliation":[{"name":"Jayhawk Athletic Performance Laboratory\u2014Wu Tsai Human Performance Alliance University of Kansas  Lawrence Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv\u201012\u20104\u2010424"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198812000-00005"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/1091367x.2020.1865966"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279\u2010023\u201001900\u20106"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11332\u2010023\u201001135\u2010y"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1974.37.2.247"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42000\u2010020\u201000214\u2010w"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000004913"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2025.1538465"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.24.11.115001"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.24.9494"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1139\/h94\u2010032"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00267.2013"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13632"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/02640419508732244"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279\u2010017\u20100698\u2010y"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2019.11.003"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421\u2010007\u20100430\u2010y"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.196725"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.69.4.1442"},{"key":"e_1_2_12_22_1","first-page":"119","volume-title":"Physiological assessment of human fitness","author":"Kraemer W. 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