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This study aimed to compare ventilatory efficiency at rest between asthmatic patients and healthy subjects, and to assess the stability of these parameters over 1\u2009year. Ventilation (<jats:italic>V<\/jats:italic><jats:sub>E<\/jats:sub>), respiratory rate (RR), tidal volume (V<jats:sub>T<\/jats:sub>), carbon dioxide output (<jats:italic>V<\/jats:italic>CO<jats:sub>2<\/jats:sub>) and end\u2010tidal partial pressure (P<jats:sub>ET<\/jats:sub>CO<jats:sub>2<\/jats:sub>), spirometry, and breath\u2010holding time (BHT) were measured at baseline (M1) and 17\u201351\u2009weeks later (M2). The ventilatory efficiency (<jats:italic>V<\/jats:italic><jats:sub>E<\/jats:sub>\/<jats:italic>V<\/jats:italic>CO<jats:sub>2<\/jats:sub>) and breathing pattern (RR\/V<jats:sub>T<\/jats:sub>) were calculated. Patients took the Asthma Control Test questionnaire (ACT). A mixed\u2010design ANOVA at M1 showed that 30 not well\u2010controlled asthmatic patients according to ACT (77% females, 7 with airway obstruction), and 23 matched healthy subjects had similar breathing parameters, except for BHT (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.02) and P<jats:sub>ET<\/jats:sub>CO<jats:sub>2<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009=\u20090.06). Only BHT changed, that is, it increased from M1 to M2 in the groups and remained shorter among the patients. Despite a shorter BHT among the patients, indicating a heightened perceptual sensitivity for dyspnoea, the ventilatory efficiency and breathing pattern at rest were similar and remained stable for 1\u2009year in both groups.<\/jats:p>","DOI":"10.14814\/phy2.70490","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T19:33:02Z","timestamp":1753903982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessing ventilatory efficiency at rest in asthma: A longitudinal comparison with healthy subjects"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8945-2828","authenticated-orcid":false,"given":"Monique","family":"van Oosten","sequence":"first","affiliation":[{"name":"Physiotherapy Monique slf  Mosfellsbaer Iceland"},{"name":"Faculty of Medicine University of Iceland  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1984-6749","authenticated-orcid":false,"given":"Arni","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Iceland  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9855-528X","authenticated-orcid":false,"given":"Bjorn","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The South Coast Health Institution of Iceland  Selfoss Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1985-4474","authenticated-orcid":false,"given":"Marta","family":"Gudjonsdottir","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Iceland  Reykjavik Iceland"},{"name":"Cardiopulmonary Laboratory Reykjalundur Rehabilitation Centre  Mosfellsbaer Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201804\u20100682CI"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045\u20107022\u20102\u201018"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00859.2015"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0088\u20102015"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326\u20105377.1998.tb123422.x"},{"issue":"7","key":"e_1_2_11_7_1","first-page":"885","article-title":"Anatomic dead space cannot be predicted by body weight","volume":"53","author":"Brewer L. 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