{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:15:27Z","timestamp":1789676127415,"version":"4.0.1"},"reference-count":108,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/09111\u20109"],"award-info":[{"award-number":["2022\/09111\u20109"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/10354\u20103"],"award-info":[{"award-number":["2022\/10354\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006417","name":"Fundo de Apoio ao Ensino, \u00e0 Pesquisa e Extens\u00e3o, Universidade Estadual de Campinas","doi-asserted-by":"publisher","award":["2062\/23"],"award-info":[{"award-number":["2062\/23"]}],"id":[{"id":"10.13039\/501100006417","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.712583\/2022\u201000"],"award-info":[{"award-number":["88887.712583\/2022\u201000"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["157401\/2022\u20107"],"award-info":[{"award-number":["157401\/2022\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The goal of the study was to investigate the effects of aerobic exercise training on inflammatory, oxidative stress, and cellular senescence biomarkers, along with the evaluation of morphology and anti\u2010contractile response of perivascular adipose tissue of the thoracic aorta (tPVAT) in female mice (C57BL6\/JUnib) divided into sedentary (SD), trained (TR), obese sedentary (OB\u2010SD), and obese trained (OB\u2010TR). In the OB\u2010SD group, serum glucose, leptin, TNF\u2010\u03b1, and malondialdehyde were increased, linked with enlarged lipid droplets, decreased adiponectin content in tPVAT, and enhanced vascular \u03b2\u2010galactosidase activity accompanied by alterations in the anti\u2010contractile response of tPVAT to serotonin (5\u2010HT) compared with the SD group. Aerobic exercise training was effective in reducing serum leptin, TNF\u2010\u03b1, and malondialdehyde in the OB\u2010TR group, with smaller lipid droplets and increased adiponectin in the tPVAT, and attenuation of vascular \u03b2\u2010galactosidase activity with beneficial effects in the vascular response to 5\u2010HT. This study highlights a significant phenotypic change of the tPVAT in obese female mice with increased vascular senescence and dysregulation of the anti\u2010contractile response, systemic inflammation, and oxidative stress. Aerobic exercise training effectively mitigated some of the obesity\u2010induced changes in the tPVAT, partially restoring the anti\u2010contractile response to 5\u2010HT and reducing circulatory leptin, TNF\u2010\u03b1, and malondialdehyde.<\/jats:p>","DOI":"10.14814\/phy2.70506","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T08:15:17Z","timestamp":1755850517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Moderate\u2010intensity aerobic exercise attenuates obesity\u2010induced changes in perivascular adipose tissue in female mice"],"prefix":"10.14814","volume":"13","author":[{"given":"Teresa M.","family":"Da\u2010Re","sequence":"first","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional, Instituto de Biologia Universidade Estadual de Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme A.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional, Instituto de Biologia Universidade Estadual de Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza H.","family":"Rossi","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional, Instituto de Biologia Universidade Estadual de Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila B.","family":"Risso","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional, Instituto de Biologia Universidade Estadual de Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvio R.","family":"Consonni","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Biologia Tecidual, Instituto de Biologia Universidade Estadual de Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-055X","authenticated-orcid":false,"given":"Maria A.","family":"Delbin","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional, Instituto de Biologia Universidade Estadual de Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.19437"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0909\u2010996"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90617.2008"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440\u20101681.12882"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.41"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2010.01.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2013.10.016"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520297609116677"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.482"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010022\u201000739\u20100"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2016.09.005"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1451429"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.182998"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102683"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1517\u201086922004000400009"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00197"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.14670\/HH\u201027.885"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12993"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00253"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/08037051.2024.2414072"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13687"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2012.01.013"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.11.019"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00656.2003"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101681.2007.04635.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00376.2011"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015\u20102079"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00103"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b13\u201000317"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.03.013"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318213fefb"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0000000000000383"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095312"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.2011.01430.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1499340"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010022\u201000906\u2010w"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP271757"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-6997(25)06783-3"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440\u20101681.13502"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31828ff9c6"},{"key":"e_1_2_10_42_1","first-page":"105","article-title":"Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high\u2010fat\u2010diet\u2010induced obese mice","volume":"16","author":"Kawanishi N.","year":"2010","journal-title":"Exercise Immunology Review"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj\u201009\u20100661"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000003058"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.10.011"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181ad7f17"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.305205"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqae024"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.5099\/aj110400241"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2025.1572139"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522\u2010025\u201010279\u2010y"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.697720"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440\u20101681.13404"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.02.006"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29881"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b13\u201000344"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107015\u20109\u201025"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071754"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12081595"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.138305"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.679492"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.07.097"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.2011.01404.x"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4031"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12576\u2010017\u20100559\u20103"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.702025"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892\u2010022\u201001493\u2010w"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.111"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344\u2010200406000\u201000006"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20402"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303030"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010022\u201004752\u20106"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00567.2012"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101601"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010411619\u20101.00006\u20109"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.10.009"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.08.004"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.192658"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.02.010"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m703458200"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.2012.02224.x"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010020\u201005307\u20100"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12\u20101430"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12012"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101268"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15\u20100291"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911189"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440\u20101681.13550"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01009"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells100614855"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06902"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1980\u20106574201700si0007"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113843"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1109\/MC.1983.1654163"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs20110151"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474\u20109726.2010.00608.x"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010021\u201000999\u20109"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200701211912"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00295"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.720224"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44200\u2010023\u201000032\u20106"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000143"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00131.2021"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005204"},{"key":"e_1_2_10_105_1","volume-title":"World obesity atlas 2024","author":"World Obesity Federation","year":"2024"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.306263"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440\u20101681.13087"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1089\/met.2019.0083"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.650214"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:14:43Z","timestamp":1756361683000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.70506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":108,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.14814\/phy2.70506"],"URL":"https:\/\/doi.org\/10.14814\/phy2.70506","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70506"}}