{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:15:28Z","timestamp":1790648128311,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG077536"],"award-info":[{"award-number":["R01 AG077536"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["3RF1AG057264\u201003W1"],"award-info":[{"award-number":["3RF1AG057264\u201003W1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AG052374"],"award-info":[{"award-number":["T32 AG052374"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARF\u201021\u2010851362"],"award-info":[{"award-number":["AARF\u201021\u2010851362"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Running promotes skeletal muscle remodeling through metabolic and inflammatory signaling pathways, though the extent to which these responses are sex\u2010dependent remains unclear. We profiled cytokine responses in quadriceps lysates from sedentary, voluntary wheel\u2010running (VWR), and muscle\u2010specific TFEB\u2010overexpressing (cTFEB;HSACre) male and female mice. Cytokine analysis revealed 40 differentially expressed factors associated with exercise and\/or TFEB overexpression, many exhibiting sex\u2010dimorphic patterns. In males, VWR increased interleukins (IL\u20101\u03b1, IL\u20101\u03b2, IL\u20102, IL\u20105, and IL\u201017) and chemokines (e.g., MCP\u20101, CCL5, and CXCL9), including components of TNF signaling (e.g., TNF\u03b1, sTNFR1\/2, and Fas ligand). These elevations were partially recapitulated by TFEB overexpression in sedentary males. In contrast, female VWR muscle showed limited changes, with significant differences restricted to IL\u20103, IL\u20103Rb, IL\u201013, and CXCL16. These findings demonstrate sex\u2010specific cytokine responses to endurance\u2010like stimuli and suggest a broader or more prolonged inflammatory remodeling profile in male skeletal muscle. Moreover, muscle\u2010specific TFEB overexpression reproduced similar endurance\u2010induced cytokine changes, particularly in males, highlighting TFEB as a partial molecular mimic of exercise\u2010associated inflammatory signaling in skeletal muscle. Together, our data underscore the importance of sex as a biological variable in exercise\u2010induced cytokine remodeling and support the utility of TFEB overexpression as a platform for prioritizing exercise\u2010associated phenotypes.<\/jats:p>","DOI":"10.14814\/phy2.70519","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T19:40:46Z","timestamp":1755718846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Convergent skeletal muscle cytokine responses to\n                    <scp>TFEB<\/scp>\n                    overexpression and voluntary wheel running reflect sex\u2010based variability to exercise adaptations in mice"],"prefix":"10.14814","volume":"13","author":[{"given":"Dalton C.","family":"Patterson","sequence":"first","affiliation":[{"name":"Department of Cell, Developmental and Integrative Biology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Birnbaum","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cell and Developmental Biology University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Matthews","sequence":"additional","affiliation":[{"name":"Leonard Davis School of Gerontology University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6033-7428","authenticated-orcid":false,"given":"Constanza J.","family":"Cortes","sequence":"additional","affiliation":[{"name":"Leonard Davis School of Gerontology University of Southern California  Los Angeles California 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