{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:53:01Z","timestamp":1791100381472,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Skeletal muscle's capacity for oxidative energy production can be measured in\u00a0vivo by phosphocreatine (PCr) recovery following maximal contractions inside a magnetic resonance scanner. However, muscle energetic characteristics during submaximal contractions of similar intensity as used in free\u2010living activities may be more relevant to the energetic support of ambulatory tasks during daily life. We measured vastus lateralis muscle <jats:italic>oxidative capacity<\/jats:italic>, acidification, <jats:italic>submaximal oxidative energy production<\/jats:italic>, and acetylcarnitine accumulation in response to an incremental contraction protocol (6%\u201315% maximal torque). We then evaluated the relationships between these metrics and whole\u2010body metabolic responses to a 30\u2010min treadmill walk (30MTW) and a peak oxygen consumption (VO<jats:sub>2peak<\/jats:sub>) test using Spearman rank correlations (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>, <jats:italic>n<\/jats:italic>\u2009=\u20097 males, 28\u2009\u00b1\u20094\u2009years). Muscle oxidative capacity was not related to any metric of whole\u2010body metabolism, but submaximal PCr recovery was associated with slower VO<jats:sub>2<\/jats:sub> off\u2010kinetics following the 30MTW (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u20090.96, <jats:italic>p<\/jats:italic>\u2009=\u20090.003). Muscle [acetylcarnitine] was associated with respiratory exchange ratio (RER) during the 30MTW and VO<jats:sub>2peak<\/jats:sub> test (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u20090.81, <jats:italic>p<\/jats:italic>\u2009=\u20090.035 and <jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u20090.86, <jats:italic>p<\/jats:italic>\u2009=\u20090.024). Muscle acidification was associated with RER only at VO<jats:sub>2peak<\/jats:sub> (and <jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u2009<jats:sup>\u2212<\/jats:sup>0.89, <jats:italic>p<\/jats:italic>\u2009=\u20090.012). These preliminary results provide novel connections between muscle and whole\u2010body energetics and suggest that submaximal muscle energetics may be more relevant to free\u2010living tasks than oxidative capacity.<\/jats:p>","DOI":"10.14814\/phy2.70528","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T05:52:10Z","timestamp":1756273930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Skeletal muscle energetics during submaximal contractions are linked to metabolic performance during ambulatory exercise: A pilot study in male adults"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-1491","authenticated-orcid":false,"given":"Christopher M. 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