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Healthy adults (<jats:italic>n<\/jats:italic>\u2009=\u200913, 21\u2009\u00b1\u20093\u2009years) participated in a randomized, placebo\u2010controlled crossover study consisting of three, 2\u2010week phases separated by \u22651\u2009week. Food products containing the fiber and polyphenol supplement or placebo were consumed during each phase. During the final 2\u2009days of each phase, participants resided in a hypobaric chamber for 36\u2009h simulating low (500\u2009m) or high (4300\u2009m) altitude, creating three conditions: placebo\u2010500\u2009m, placebo\u20104300\u2009m, and supplement\u20104300\u2009m. A computerized cognitive test battery was administered each morning, evening, and ~36\u2009h post\u2010chamber residence to assess mood and cognition. Total mood disturbance, tension, fatigue, and depression were higher, and total risk\u2010propensity score, energy, self\u2010control, and invincibility were lower at 4300\u2009m versus 500\u2009m independent of supplementation. Relative to placebo\u2010500\u2009m, anger was higher during placebo\u20104300\u2009m, but not supplement\u20104300\u2009m, whereas confusion was greater during supplement\u20104300\u2009m but not placebo\u20104300\u2009m. More vigilance false alarms occurred during 500\u2009m versus 4300\u2009m independent of supplementation. Although short supplementation and washout periods may have limited observable effects, findings do not support favorable effects of this fiber and polyphenol supplement on cognition but suggest the supplement may attenuate hypobaric hypoxia\u2010induced increases in anger.<\/jats:p>","DOI":"10.14814\/phy2.70541","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T01:31:25Z","timestamp":1757554285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of fermentable fiber and polyphenol supplementation on mood and cognition in adults during hypobaric hypoxia exposure"],"prefix":"10.14814","volume":"13","author":[{"given":"Meaghan E.","family":"Beckner","sequence":"first","affiliation":[{"name":"Military Nutrition Division U.S. Army Research Institute of Environmental Medicine  Natick Massachusetts USA"},{"name":"Oak Ridge Institute for Science and Education  Oak Ridge Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather S.","family":"Fagnant","sequence":"additional","affiliation":[{"name":"Military Nutrition Division U.S. Army Research Institute of Environmental Medicine  Natick Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Niro","sequence":"additional","affiliation":[{"name":"Military Nutrition Division U.S. Army Research Institute of Environmental Medicine  Natick Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace E.","family":"Giles","sequence":"additional","affiliation":[{"name":"U.S. Army Combat Capabilities Development Command Soldier Center  Natick Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harris R.","family":"Lieberman","sequence":"additional","affiliation":[{"name":"Military Nutrition Division U.S. Army Research Institute of Environmental Medicine  Natick Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-2241","authenticated-orcid":false,"given":"J. 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