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Young adult male Sprague\u2013Dawley rats were divided into four groups: rats exposed to restraint stress, rats assigned to eplerenone treatment, rats exposed to restraint stress and eplerenone treatment, and a control group. After 4\u2009weeks of the experiment, rats' blood pressure and heart rate were recorded, transthoracic echocardiography was performed, and blood samples and hearts were collected for further analysis. The study showed that chronic stress increases cardiac glucocorticoid mRNA expression but does not change the expression of MR mRNA. Chronic stress increases matrix metalloproteinases activity in the cardiac muscle. Mild left ventricular pro\u2010hypertrophic changes were noted on echocardiogram. The changes were partially prevented by MR blockade with the use of eplerenone. These findings indicate that MRs participate in cardiac responses to chronic stress; however, this is not directly associated with significant changes in cardiac MRs expression.<\/jats:p>","DOI":"10.14814\/phy2.70549","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T04:30:44Z","timestamp":1760070644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac response to chronic restraint stress involves mineralocorticoid receptors in male Sprague\u2013Dawley rats"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7100-2236","authenticated-orcid":false,"given":"D.","family":"Sztechman","sequence":"first","affiliation":[{"name":"Laboratory of Centre for Preclinical Research, Department of Experimental and Clinical Physiology Medical University of Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3535-715X","authenticated-orcid":false,"given":"T.","family":"Zera","sequence":"additional","affiliation":[{"name":"Laboratory of Centre for Preclinical Research, Department of Experimental and Clinical Physiology Medical University of Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Czarzasta","sequence":"additional","affiliation":[{"name":"Laboratory of Centre for Preclinical Research, Department of Experimental and Clinical Physiology Medical University of Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Szczepanska\u2010Sadowska","sequence":"additional","affiliation":[{"name":"Laboratory of Centre for Preclinical Research, Department of Experimental and Clinical Physiology Medical University of Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cudnoch\u2010Jedrzejewska","sequence":"additional","affiliation":[{"name":"Laboratory of Centre for Preclinical Research, Department of Experimental and Clinical Physiology Medical University of Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1990.tb03915.x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01328-z"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000014686.73212.DA"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.4238\/2014.January.24.4"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.05.018"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-018-1410-4"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/0049825021000049277"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12324"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.114059"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2018.11.024"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00548.2023"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1187100"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.13168"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00155.2017"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.983023"},{"key":"e_1_2_13_17_1","article-title":"An unpredictable chronic mild stress protocol for instigating depressive symptoms, behavioral changes and negative health outcomes in rodents","volume":"106","author":"Frisbee J. 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