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A total of 90 adult male mice were equally divided into three groups: control (c) plus non\u2010AN group, c plus AN group, and HA plus AN group. Neurobehavioral performances included passive avoidance tasks (to assess learning and memory function), Y\u2010maze tests (to assess spatial memory ability), and novel object recognition tests. Physiological functions included stress responses, inflammation, and oxidative stress, which were determined biochemically. The severity of endotoxemia was determined by measuring the serum levels of lipopolysaccharide. Both gut barrier and blood\u2013brain barrier permeability were determined by fluorescein isothiocyanate and Evans Blue dye measurement, respectively. Compared to c+non\u2010AN mice, the c+AN mice displayed neurobehavioral disorders along with exacerbated stress reactions, gut barrier disruption, endotoxemia, blood\u2013brain barrier disruption, and hippocampal inflammation and oxidative stress. Compared to c+AN mice, the HA+AN mice had significantly less severity of all the abovementioned behavioral and physiological impairments. These results suggest that HA counteracts neurobehavioral and physiological disorders in mice exposed to aircraft noise.<\/jats:p>","DOI":"10.14814\/phy2.70575","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T09:05:47Z","timestamp":1759395947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heat acclimation prevents neurobehavioral and physiological disorders in mice exposed to chronic aircraft noise"],"prefix":"10.14814","volume":"13","author":[{"given":"Kangli","family":"Zhang","sequence":"first","affiliation":[{"name":"The Guidance Center for Military Psychology of PLA; Key Laboratory of Military Medical Psychology and Stress Biology of PLA; Department of Psychology, The 960th Hospital of Joint Logistics Support Force of PLA  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Lin","sequence":"additional","affiliation":[{"name":"The Guidance Center for Military Psychology of PLA; Key Laboratory of Military Medical Psychology and Stress Biology of PLA; Department of Psychology, The 960th Hospital of Joint Logistics Support Force of PLA  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-9414","authenticated-orcid":false,"given":"Ching\u2010Ping","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medical Research Chi Mei Medical Center  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueqing","family":"Yi","sequence":"additional","affiliation":[{"name":"The Guidance Center for Military Psychology of PLA; Key Laboratory of Military Medical Psychology and Stress Biology of PLA; Department of Psychology, The 960th Hospital of Joint Logistics Support Force of PLA  Jinan Shandong Province China"},{"name":"Department of Medical Imaging The 960th Hospital of Joint Logistics Support Force of PLA  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute Indiana University School of Medicine  Indianapolis Indianan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute Indiana University School of Medicine  Indianapolis Indianan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingjian","family":"Ding","sequence":"additional","affiliation":[{"name":"Big Data Analytics Laboratory of Sport Performance Assessment Sport College of Shandong University  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging The 960th Hospital of Joint Logistics Support Force of PLA  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanning","family":"Sun","sequence":"additional","affiliation":[{"name":"Big Data Analytics Laboratory of Sport Performance Assessment Sport College of Shandong University  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Applied Psychology, College of Sports and Health Shandong Sport University  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongya","family":"Shi","sequence":"additional","affiliation":[{"name":"Shandong Huayi Biotechnology Co., Ltd  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8234-4442","authenticated-orcid":false,"given":"Cheng\u2010Hsien","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine (Basic Sciences) Mackay Medical University  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Sun","sequence":"additional","affiliation":[{"name":"The Guidance Center for Military Psychology of PLA; Key Laboratory of Military Medical Psychology and Stress Biology of PLA; Department of Psychology, The 960th Hospital of Joint Logistics Support Force of PLA  Jinan Shandong Province China"},{"name":"Department of Medical Imaging The 960th Hospital of Joint Logistics Support Force of PLA  Jinan Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12295"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1463\u20101741.127847"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00160.2021"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001212"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2018.e00644"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.06.023"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.09.008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0735\u20107044.113.5.902"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010529108"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4236\/wjns.2014.41001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4161\/temp.29800"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010021\u201003370\u20106"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293\u2010018\u20100166\u2010x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2002.005488"},{"key":"e_1_2_10_16_1","volume-title":"Burden of Disease from Environmental Noise","author":"Fritschi L. 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