{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:38:58Z","timestamp":1790192338555,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    High\u2010altitude exposure induces hypoxemia, triggering metabolic adjustments to enhance oxygen delivery. This acclimatization process often involves mood changes, cognitive alterations, and Acute Mountain Sickness (AMS) symptoms. This study examined the effects of simulated hypoxia at 4500\u2009m on physiological variables, reaction time, lapses, and mood states. Twenty\u2010three volunteers were exposed to a simulated 4500\u2009m altitude for 4\u2009h in a normobaric hypoxia chamber. Lactate, glucose, SpO\n                    <jats:sub>2<\/jats:sub>\n                    , heart rate (HR), and AMS symptoms were assessed before and every hour during exposure. As expected, SpO\n                    <jats:sub>2<\/jats:sub>\n                    significantly decreased (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), while HR increased (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006) during exposure. Reaction time remained unaffected, but lapses significantly correlated with lactate levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002). Mood states, particularly tension (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) and fatigue (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), were associated with AMS symptoms. Simulated high\u2010altitude exposure induced physiological alterations, including decreased SpO\n                    <jats:sub>2<\/jats:sub>\n                    , increased HR, and a significant correlation between lactate levels and cognitive performance. While reaction time was unchanged, mood disturbances were strongly related to AMS. These findings highlight the need for strategies to mitigate both physiological and psychological effects of hypoxia.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70601","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:38:39Z","timestamp":1759991919000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early adaptation to high\u2010altitude: Mood and cognitive responses at simulated 4500\u2009m"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-2040","authenticated-orcid":false,"given":"Ricardo Muller","family":"Bottura","sequence":"first","affiliation":[{"name":"Department of Psychobiology Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Department of Neurosciences, Biomedicine and Movement Sciences Universit\u00e0 degli Studi di Verona  Verona Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Sciences (DINOGMI) Universit\u00e0 degli Studi di Genova  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambra","family":"Bisio","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine (DIMES) Universit\u00e0 degli Studi di Genova  Genova Italy"},{"name":"Centro Polifunzionale di Scienze Motorie Universit\u00e0 degli Studi di Genova  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora Cristina","family":"Hipolide","sequence":"additional","affiliation":[{"name":"Department of Psychobiology Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063630"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256\u2010199316020\u201000003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.5.581"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142375"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12121736"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0031\u20109384(00)00362\u20100"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197147"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410394678"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2014.1039"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2012.04.015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0018502"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.670278"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15175"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200107123450206"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/jsm.0000000000000098"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2009.1060"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27766"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20108986.2012.01411.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916\u2010013\u20100383\u20102"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.01.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091450"},{"key":"e_1_2_9_23_1","first-page":"272","volume-title":"Hypoxia and Molecular Medicine","author":"Roach R. C.","year":"1993"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2017.0164"},{"key":"e_1_2_9_25_1","unstructured":"Rohlfs I. C. P. d. M. Terry P. C. Rotta T. M. Luft C. D. B. Andrade A. Krebs R. J. deCarvalho T. &Iizuka C. A.(2008).Development and initial validation of the Brazil Mood Scale. Proceedings of the 11th European Congress of Sport Psychology (FEPSAC) Halkidiki Greece.https:\/\/www.researchgate.net\/publication\/235925600"},{"issue":"6","key":"e_1_2_9_26_1","first-page":"530","article-title":"Mood states at 1600 and 4300 m terrestrial altitude","volume":"59","author":"Shukitt\u2010Hale B.","year":"1988","journal-title":"Aviation, Space, and Environmental Medicine"},{"key":"e_1_2_9_27_1","first-page":"225","article-title":"Altitude symptomatology and mood states during a climb to 3630 m","volume":"61","author":"Shukitt\u2010Hale B.","year":"1990","journal-title":"Aviation, Space, and Environmental Medicine"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1469\u20100292(01)00035\u20108"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/biohorizons\/hzu001"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2015.02.006"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010021\u201000796\u20103"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201207\u20101323CI"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70601","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.70601","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:23:38Z","timestamp":1773015818000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.70601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":31,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.14814\/phy2.70601"],"URL":"https:\/\/doi.org\/10.14814\/phy2.70601","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70601"}}