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Adiponectin (ApN) emerged as a therapeutic candidate for muscle disorders. However, the effect of DMA on the ApN pathway remains poorly studied. Given ApN's metabolic effects, examining the ApN pathway response to disuse in relation with muscle type is essential. To mimic DMA while avoiding confounding factors, we combined HindLimb Unloading with Immobilization (HLUI) through a device allowing mouse displacements. The effects of disuse on DMA severity were studied in the slow\u2010twitch\n                    <jats:italic>Soleus<\/jats:italic>\n                    and the fast\u2010twitch Tibialis anterior (\n                    <jats:italic>TA<\/jats:italic>\n                    ) muscles, together with the ApN pathway. The\n                    <jats:italic>Soleus<\/jats:italic>\n                    muscle presents a moderate atrophy of type IIa myofibers, whereas the\n                    <jats:italic>TA<\/jats:italic>\n                    muscle is more severely affected and exhibits a type I to IIa switch. HLUI increased the hybrid I\/IIa myofiber proportion in both muscles, suggesting an ongoing myofiber switch that is delayed in the\n                    <jats:italic>Soleus<\/jats:italic>\n                    muscle. Concomitantly, HLUI enhances ApN plasma level, modifies oligomeric form proportions, and downregulates Adiporeceptors in the\n                    <jats:italic>Soleus<\/jats:italic>\n                    but not in the\n                    <jats:italic>TA<\/jats:italic>\n                    muscle. In conclusion, HLUI is associated with a higher ApN plasma level and disturbances in oligomeric form proportions. DMA severity, myofiber switch kinetics, and adiporeceptor regulation are muscle\u2010type dependent.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70602","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T06:01:11Z","timestamp":1761026471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disuse\u2010induced muscle\u2010type specific alterations and adiponectin pathway response in male mice"],"prefix":"10.14814","volume":"13","author":[{"given":"Szczepanski","family":"S\u00e9bastien","sequence":"first","affiliation":[{"name":"Laboratory of Respiratory Physiology, Pathophysiology and Rehabilitation, Research Institute for Health Sciences and Technology University of Mons  Mons Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limpens","family":"Ma\u00eblle","sequence":"additional","affiliation":[{"name":"Laboratory of Respiratory Physiology, 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