{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:25:52Z","timestamp":1788999952501,"version":"build-2803163510"},"reference-count":68,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The high mortality of systemic infection results from its associated cardiovascular depression. Cardiac depression typically normalizes if the patient recovers from the infection, but recent studies suggest that these patients have an increased long\u2010term risk of developing cardiovascular disease after the septic episode. These findings have reignited interest in sepsis\u2010associated cardiac function and myocardial blood flow, which remain poorly understood in humans. We studied cardiac function and myocardial microvascular perfusion using gadolinium\u2010contrast magnetic resonance imaging in a cohort of patients during the initial recovery period of sepsis (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916) or septic shock (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095) and after full recovery 1\u20132\u2009months later (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200913). In addition, hepatic, splenic, and renal cortical perfusion were also assessed. With infection, cardiac output (+27%), the rate\u2010pressure\u2010product (+21%), and the left ventricle (LV) peak\u2010ejection (+36%) and peak\u2010filling (+35%) rates increased compared to full recovery (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Onset of LV myocardial perfusion and the time to peak LV myocardial perfusion of gadolinium\u2010contrast occurred earlier during initial than after recovery, with a numerically higher LV myocardium wash\u2010in rate (23\u2009\u00b1\u200922 vs. 14\u2009\u00b1\u200914\u2009s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.07). LV myocardial fibrosis was not seen in any patients. Renal cortical, splenic, and hepatic perfusion parameters including onset, time\u2010to\u2010peak, and wash\u2010in rates of gadolinium contrast were comparable between initial and full recovery, except for a lower hepatic wash\u2010in rate during initial recovery (13\u2009\u00b1\u200910 vs. 22\u2009\u00b1\u200916\u2009s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03). Our study supports that myocardial microvascular dysfunction is unlikely to contribute to cardiovascular disease after severe infection. Conversely, hepatic hypoperfusion during sepsis may explain the commonly observed hepatic dysfunction in sepsis.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70605","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:38:38Z","timestamp":1759815518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Myocardial blood flow in patients with sepsis"],"prefix":"10.14814","volume":"13","author":[{"given":"Peter Andreas","family":"Christiansen","sequence":"first","affiliation":[{"name":"The August Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnoosh","family":"Nedaei","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev\u2010Gentofte Hospital, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper","family":"Sejersen","sequence":"additional","affiliation":[{"name":"The August Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah G.","family":"Caldwell","sequence":"additional","affiliation":[{"name":"The August Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse","family":"Gliemann","sequence":"additional","affiliation":[{"name":"The August Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Sofie","family":"Andreasen","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Herlev\u2010Gentofte Hospital  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"S\u00f8borg","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Herlev\u2010Gentofte Hospital  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Segelcke","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Radiology Herlev\u2010Gentofte Hospital  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob M.","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Radiology Herlev\u2010Gentofte Hospital  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8655-4458","authenticated-orcid":false,"given":"Per Lav","family":"Madsen","sequence":"additional","affiliation":[{"name":"The August Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Cardiology Herlev\u2010Gentofte Hospital, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"63","article-title":"Intrinsic myocardial dysfunction during endotoxemia: Dependent or independent of myocardial ischemia?","volume":"30","author":"Adams H. 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