{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:45:45Z","timestamp":1792194345695,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["406196"],"award-info":[{"award-number":["406196"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study tested the ability of simple heart rate (HR)\u2010based measures\u2014namely, resting HR variability (HRV), post\u2010exercise HRV, and HR recovery (HRR)\u2014to identify cardiovascular autonomic neuropathy (CAN) in individuals with prediabetes and type 2 diabetes (T2D). Fifty subjects with T2D or prediabetes participated in the study. CAN was diagnosed using five cardiovascular reflex tests: HR response to Valsalva, deep breathing, and standing; and blood pressure response to sustained handgrip and standing. Resting HRV was evaluated using time\u2010 (SDNN, RMSSD) and frequency\u2010domain analysis (total power, low\u2010[LF] and high\u2010frequency power [HF]). Post\u2010exercise HRV and HRR were assessed over 2\u2009minutes after the Incremental Shuttle Walking Test. HRR was calculated as the difference between peak HR and HR at 1 and 2\u2009min post\u2010test (HRR\n                    <jats:sub>1min<\/jats:sub>\n                    , HRR\n                    <jats:sub>2min<\/jats:sub>\n                    ). ROC curve analysis showed that the resting HF\u2010HRV index had the strongest diagnostic performance among resting indices (sensitivity\u2009=\u200967.9%, specificity\u2009=\u200986.4%, AUC\u2009=\u20090.755,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), while HRR\n                    <jats:sub>2min<\/jats:sub>\n                    showed the best performance among the post\u2010exercise indices (AUC\u2009=\u20090.672,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.042). Overall, resting HRV indices consistently outperformed post\u2010exercise HRR and HRV indices in diagnostic performance. The results suggest that resting HRV has strong potential for detecting CAN in individuals with prediabetes and T2D, and could be incorporated into CAN screening protocols.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70610","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:39:37Z","timestamp":1759991977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic value of heart rate\u2010based methods for assessing cardiac autonomic neuropathy in prediabetes and diabetes"],"prefix":"10.14814","volume":"13","author":[{"given":"D. P. S. C.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Graduate Program in Rehabilitation Science and Physical\u2010Functional Performance, Faculty of Physical Therapy Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A. Q. S.","family":"Souza","sequence":"additional","affiliation":[{"name":"Graduate Program in Rehabilitation Science and Physical\u2010Functional Performance, Faculty of Physical Therapy Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"Facchin","sequence":"additional","affiliation":[{"name":"Faculty of Physiotherapy Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. C.","family":"Mariano","sequence":"additional","affiliation":[{"name":"Graduate Program in Rehabilitation Science and Physical\u2010Functional Performance, Faculty of Physical Therapy Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. P.","family":"Silva","sequence":"additional","affiliation":[{"name":"Graduate Program in Rehabilitation Science and Physical\u2010Functional Performance, Faculty of Physical Therapy Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"},{"name":"Graduate Program in Physical Education, Faculty of Physical Education and Sports Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4968-5525","authenticated-orcid":false,"given":"T.","family":"Pe\u00e7anha","sequence":"additional","affiliation":[{"name":"Graduate Program in Rehabilitation Science and Physical\u2010Functional Performance, Faculty of Physical Therapy Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"},{"name":"Department of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, Faculty of Science &amp; Engineering Manchester Metropolitan University  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-S002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-017-0401-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195166"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2019.04.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2022.110232"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2021-002480"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-2367"},{"issue":"1","key":"e_1_2_11_9_1","first-page":"3349","article-title":"Diabetes mellitus e suas complica\u00e7\u00f5es \u2010 uma revis\u00e3o sistem\u00e1tica e informativa\/ diabetes mellitus and its complications\u2014A systematic and informative review. 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