{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:17:32Z","timestamp":1784258252217,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["F31 HL162518"],"award-info":[{"award-number":["F31 HL162518"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL163272"],"award-info":[{"award-number":["R01 HL163272"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["25PRE1410255"],"award-info":[{"award-number":["25PRE1410255"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P30 GM127607"],"award-info":[{"award-number":["P30 GM127607"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["S10 OD025178"],"award-info":[{"award-number":["S10 OD025178"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Changes to the extracellular matrix support acute wound healing following myocardial infarction. Fibroblasts regulate the composition of the extracellular matrix, in part, by secreting hyaluronan. Details surrounding the regulation, source, and impact of hyaluronan production after MI are largely unknown. We recently showed that activated fibroblasts produce hyaluronan via\n                    <jats:italic>Has2<\/jats:italic>\n                    ; however, the extent to which this function impacts acute ventricular remodeling following myocardial infarction (MI) has not been tested. Hence, the goal of the present study was to elucidate the impact of fibroblast\u2010borne\n                    <jats:italic>Has2<\/jats:italic>\n                    expression in acute ventricular remodeling. Adult, male and female mice were subjected to non\u2010reperfused myocardial infarction and followed for 1\u2009week and subjected to echocardiography and hearts were harvested for pathology and biochemical analyses. Mice were deficient in fibroblast\u2010derived\n                    <jats:italic>Has2<\/jats:italic>\n                    (\n                    <jats:italic>Has2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    ) or were littermate controls that were sufficient in fibroblast\n                    <jats:italic>Has2<\/jats:italic>\n                    . At 1\u2010week post\u2010MI,\n                    <jats:italic>Has2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    male mice had exacerbated heart failure reflected by lower cardiac output due to lower stroke volume, when compared to littermate males. The genotype effect was not evident in female mice. To assess potential mechanisms, we examined hearts for fibrosis, cardiomyocyte cross\u2010sectional area, and capillary density; there were no significant differences in any of these endpoints. Deletion of\n                    <jats:italic>Has2<\/jats:italic>\n                    also did not impact collagen organization, which could have indicated changes in ventricular stiffness. Fibroblast\u2010derived\n                    <jats:italic>Has2<\/jats:italic>\n                    supports cardiac function early after MI. The mechanism responsible for this and why it is not evident in female mice is unclear.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70611","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T09:29:57Z","timestamp":1763458197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fibroblast\n                    <i>Has2<\/i>\n                    limits acute heart failure following myocardial infarction in male mice"],"prefix":"10.14814","volume":"13","author":[{"given":"Danielle T.","family":"Little","sequence":"first","affiliation":[{"name":"Center for Cardiometabolic Science, Christina Lee Brown Envirome Institute University of Louisville School of Medicine  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R.","family":"Brittian","sequence":"additional","affiliation":[{"name":"Center for Cardiometabolic Science, Christina Lee Brown Envirome Institute University of Louisville School of Medicine  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Howard","sequence":"additional","affiliation":[{"name":"Center for Cardiometabolic Science, Christina Lee Brown Envirome Institute University of Louisville School of Medicine  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Pendergraft","sequence":"additional","affiliation":[{"name":"Center for Cardiometabolic Science, Christina Lee Brown Envirome Institute University of Louisville School of Medicine  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey","family":"Colley","sequence":"additional","affiliation":[{"name":"Center for Cardiometabolic Science, Christina Lee Brown Envirome Institute University of Louisville School of Medicine  Louisville Kentucky 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Institute University of Louisville School of Medicine  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Wysoczynski","sequence":"additional","affiliation":[{"name":"Center for Cardiometabolic Science, Christina Lee Brown Envirome Institute University of Louisville School of Medicine  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Nong","sequence":"additional","affiliation":[{"name":"Center for Cardiometabolic Science, Christina Lee Brown Envirome Institute University of Louisville School of Medicine  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5376-8089","authenticated-orcid":false,"given":"Steven P.","family":"Jones","sequence":"additional","affiliation":[{"name":"Center for Cardiometabolic Science, Christina Lee Brown Envirome Institute University of Louisville School of Medicine  Louisville 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