{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:05:01Z","timestamp":1764151501165,"version":"3.46.0"},"reference-count":49,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013132","name":"Combat Casualty Care Research Program","doi-asserted-by":"publisher","award":["D_007_2017"],"award-info":[{"award-number":["D_007_2017"]}],"id":[{"id":"10.13039\/100013132","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    When pain is associated with traumatic hemorrhage, medics must be concerned about secondary effects of analgesics on cardiorespiratory systems. A novel analog of acetaminophen, D\u2010112, was developed to circumvent liver toxicity and improve analgesic efficacy. D\u2010112 causes dose\u2010related inhibition of formalin\u2010induced licking. The objective of this study was to test the effects of D\u2010112 on survival and cardiorespiratory variables following hemorrhage and extremity trauma (ET). We hypothesized that D\u2010112 would significantly change cardiorespiratory responses to HEM and thereby decrease survival. Male rats received either vehicle (lactated Ringer's) or D\u2010112 (50\u2009mg\/kg) after conscious hemorrhage of either 37% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910, vehicle and D\u2010112) or 50% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098, vehicle;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200911, D\u2010112) of blood volume following ET, which consisted of soft tissue injury and fibula fracture. Rats were observed for 4\u2009h after the start of hemorrhage. Neither survival times (37% hemorrhage:\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.474; 50% hemorrhage:\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.306) nor survival curves (37% hemorrhage:\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.146; 50% hemorrhage:\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.280) differed between treatments. Mean arterial pressure did not differ between treatments (37% hemorrhage:\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.742; 50% hemorrhage:\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.521). D\u2010112 transiently elevated minute ventilation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) after both hemorrhages. D\u2010112 does not alter cardiorespiratory responses to the point of depressing survival, suggesting that D\u2010112 could be an appropriate analgesic following traumatic hemorrhage.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70619","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T05:58:42Z","timestamp":1763359122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of a novel acetaminophen analog on cardiorespiratory compensatory responses and survival in a male rat model of traumatic hemorrhage"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7287-7541","authenticated-orcid":false,"given":"Miryam M.","family":"Pando","sequence":"first","affiliation":[{"name":"U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy L.","family":"Ryan","sequence":"additional","affiliation":[{"name":"U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam L.","family":"Calderon","sequence":"additional","affiliation":[{"name":"U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra M.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian S.","family":"Connor","sequence":"additional","affiliation":[{"name":"U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha L.","family":"Perez","sequence":"additional","affiliation":[{"name":"U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0537-9336","authenticated-orcid":false,"given":"Kevin D.","family":"Bunker","sequence":"additional","affiliation":[{"name":"Kalyra Pharmaceuticals  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad D.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Kalyra Pharmaceuticals  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold G.","family":"Klemcke","sequence":"additional","affiliation":[{"name":"U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2397-2462","authenticated-orcid":false,"suffix":"2nd","given":"Lonnie E.","family":"Grantham","sequence":"additional","affiliation":[{"name":"U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Hinojosa\u2010Laborde","sequence":"additional","affiliation":[{"name":"U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103959(94)00095\u2010V"},{"volume-title":"Acetaminophen toxicity","year":"2025","author":"Agrawal S.","key":"e_1_2_12_3_1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2010.0214"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.373"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527\u20103458.2006.00250.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.55460\/CBRW\u2010A2G1"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12841"},{"issue":"11","key":"e_1_2_12_9_1","first-page":"16","article-title":"Acetaminophen overdoses, active component, U.S. armed forces, 2006\u20132015","volume":"23","author":"Clark L. 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