{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:32:20Z","timestamp":1777941140551,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It has been demonstrated that water intake accelerates the release of serotonin from enterochromaffin cells in the rat jejunum, which is then transported through the portal vein into the blood. However, the physiological roles of serotonin in the regulation of blood volume remain unclear. We aimed to investigate the roles of serotonin in the physiological regulation of physical exercise\u2010dependent sweating\u2010mediated haemoconcentration in humans. All participants performed two times 30\u2010min sessions of \u2010up\u2010and\u2010down physical exercise with a 20\u2010min rest. Changes in thermal perspiration rate, concentrations of serotonin and vasopressin in blood, and samples of blood and urine were measured just before and after repeated exercise. All participants presented increased vasopressin after the first trial but showed no change after the second exercise session. In contrast, blood serotonin levels increased dramatically after the second session. Urine osmolality increased significantly after the first exercise session. All the participants showed significantly decreased ratios of red blood cells, hemoglobin, and neutrophils before and after the second exercise. In contrast, no significant changes were observed in the ratios of total protein and lymphocytes. In conclusion, serotonin may play a crucial role in the compensatory regulation of sweating\u2010mediated haemoconcentration in cooperation with vasopressin.<\/jats:p>","DOI":"10.14814\/phy2.70620","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T11:09:29Z","timestamp":1761131369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Compensatory effects of serotonin on the regulation of blood volume in healthy human subjects"],"prefix":"10.14814","volume":"13","author":[{"given":"Yuki","family":"Sakai","sequence":"first","affiliation":[{"name":"Department of Innovation of Medical and Health Sciences Research Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Department of Dentistry and Oral Surgery Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideya","family":"Momose","sequence":"additional","affiliation":[{"name":"Department of Innovation of Medical and Health Sciences Research Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Watanabe\u2010Asaka","sequence":"additional","affiliation":[{"name":"Department of Innovation of Medical and Health Sciences Research Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Division of Physiology, Faculty of Medicine Tohoku Medical and Pharmaceutical University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moyuru","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Innovation of Medical and Health Sciences Research Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Division of Physiology, Faculty of Medicine Tohoku Medical and Pharmaceutical University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nariaki","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Innovation of Medical and Health Sciences Research Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Department of Anesthesiology and Resuscitology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norika","family":"Kuneshita","sequence":"additional","affiliation":[{"name":"Department of Innovation of Medical and Health Sciences Research Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Department of Dentistry and Oral Surgery Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Maejima","sequence":"additional","affiliation":[{"name":"Department of Innovation of Medical and Health Sciences Research Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nau","family":"Ishimine","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Shinshu University Hospital  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Innovation of Medical and Health Sciences Research Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Division of Physiology, Faculty of Medicine Tohoku Medical and Pharmaceutical University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5202-124X","authenticated-orcid":false,"given":"Toshio","family":"Ohhashi","sequence":"additional","affiliation":[{"name":"Department of Innovation of Medical and Health Sciences Research Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(83)90136-4"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-022-02670-2"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.09.041"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1916.00080130010002"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32835bc703"},{"key":"e_1_2_13_7_1","first-page":"125","volume-title":"Grange HJ circulatory physiology II","author":"Guyton A. 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