{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:24:42Z","timestamp":1780395882489,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004257","name":"Helse Vest","doi-asserted-by":"publisher","award":["F\u201012817\u2010D10980"],"award-info":[{"award-number":["F\u201012817\u2010D10980"]}],"id":[{"id":"10.13039\/501100004257","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004257","name":"Helse Vest","doi-asserted-by":"publisher","award":["F\u201012654"],"award-info":[{"award-number":["F\u201012654"]}],"id":[{"id":"10.13039\/501100004257","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The interaction between anatomical structures, pressure, and airflow impacts the airway resistance. The airflow during noninvasive ventilation (NIV) relies on the upper airway and laryngeal patency. This study aimed to quantify the airflow resistance at these levels during NIV. In this cross\u2010sectional study examining 10 healthy, awake adults, we established a NIV setup incorporating a continuous video\u2010recorded transnasal laryngoscopy and simultaneous airway pressure measurement using a transducer positioned above and below the vocal folds. Airflow and mask pressure were recorded by a pneumotachograph at the mask. NIV was delivered with inspiratory positive pressure (IPAP)\/expiratory positive pressure (EPAP) set to 10\/4 and 15\/4 cmH\n                    <jats:sub>2<\/jats:sub>\n                    O. Upper airway (R\n                    <jats:sub>uaw<\/jats:sub>\n                    ) and translaryngeal (R\n                    <jats:sub>tl<\/jats:sub>\n                    ) resistance were calculated and compared with laryngoscopic findings. During IPAP10\/EPAP4, the R\n                    <jats:sub>uaw<\/jats:sub>\n                    was 4.25\/4.21 and R\n                    <jats:sub>tl<\/jats:sub>\n                    2.20\/3.45. During IPAP15\/EPAP4, the R\n                    <jats:sub>uaw<\/jats:sub>\n                    was 5.18\/5.73, and the R\n                    <jats:sub>tl<\/jats:sub>\n                    was 2.31\/3.83. R\n                    <jats:sub>uaw<\/jats:sub>\n                    was significantly higher than R\n                    <jats:sub>tl<\/jats:sub>\n                    for inspiration at both IPAP levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012), and for expiration with IPAP15\/EPAP4 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.048). The resistance appeared dynamic during the NIV cycle, and the findings aligned with the laryngoscopic observations. NIV modulates upper airway and translaryngeal resistance. Resistance increases with elevated IPAP levels, particularly within the upper airway.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70621","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T06:08:55Z","timestamp":1760681335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring upper airway and laryngeal resistance to noninvasive ventilation in healthy awake adults"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3058-6156","authenticated-orcid":false,"given":"Anne Kristine","family":"Brekka","sequence":"first","affiliation":[{"name":"Thoracic Department Haukeland University Hospital  Bergen Norway"},{"name":"Faculty of Health and Social Sciences Western Norway University of Applied Sciences  Bergen 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