{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:32:28Z","timestamp":1777941148057,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Aberrant elimination patterns after intravenous infusion of albumin 20% may predispose to persistent vascular overload or hyper\u2010oncoticity. In the present report, the frequency of deviating elimination patterns was studied by visual examination followed by calculations of the volume and albumin kinetics over 5\u2009hours in 86 volunteers and clinical patients who received 3\u2009mL\/kg albumin 20% over 30\u2009min (mean, 231\u2009mL). Constant and virtually unchanged plasma volume expansion (i.e., steady state) developed after 21% of all infusions and developed most often during surgery (64%) but rarely in volunteers (3%). The subsequent kinetic analysis associated such steady state with slow capillary filtration (\u221227% vs. all others,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Steady state or a gradual increase of the plasma oncotic pressure occurred in 28% and was characterized by fast turnover of fluid, which taken together resulted in a dehydrating effect. By contrast, steady state for plasma albumin was associated with a 48% lower capillary leakage rate constant for albumin (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) as compared to the other experiments. In conclusion, steady state for plasma volume and increasing colloid osmotic pressure after infusion of albumin 20% was more dependent on variations in fluid kinetics than on albumin kinetics.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70623","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:39:53Z","timestamp":1761197993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Constant plasma volume and colloid osmotic pressure after infusion of albumin 20%: A secondary analysis"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1528-3803","authenticated-orcid":false,"given":"Robert G.","family":"Hahn","sequence":"first","affiliation":[{"name":"Research &amp; Development Karolinska Institute at Danderyds Hospital (KIDS)  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1987.tb01140.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305727"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102859"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/08860229709026293"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005802"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1988.tb02800.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394\u2010020\u201002275\u20104"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2023.104649"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.70069"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13897"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005315"},{"key":"e_1_2_12_13_1","first-page":"74","article-title":"Isovolemic hemodilution alters the ratio of whole\u2010body to large\u2010vessel hematocrit (F\u2010cell ratio). A prospective, randomized study comparing the volume effects of hydroxyethyl starch 200,000\/0.62 and albumin","volume":"22","author":"Haller M.","year":"1995","journal-title":"Infusionstherapie und Transfusionsmedizin"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004047"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc6812"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/039139880402701206"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9572(76)90028-9"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005173"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198707163170306"},{"key":"e_1_2_12_20_1","first-page":"224","article-title":"Prediction of blood volume in normal human adults","volume":"51","author":"Nadler S. 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