{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:19:04Z","timestamp":1790291944717,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Bisphenol A (BPA), a widespread endocrine disruptor, induces male reproductive toxicity by impairing spermatogenesis and altering hormonal homeostasis. This study investigated the protective effects of\n                    <jats:italic>Myrtus communis<\/jats:italic>\n                    essential oil (EOMC) or vitamin E (Vit E) in adult male rats exposed to BPA (100\u2009mg\/kg\/day). BPA administration led to testicular damage, decreased sperm quality, hormonal imbalance, oxidative stress, and changes in lipid metabolism. Vit E preserved seminiferous tubule structure and reduced the presence of immature germ cells, though partial disruption of spermatogenesis persisted. EOMC displayed dose\u2010dependent protective effects at 50, 100, and 200\u2009mg\/kg. At the highest dose, EOMC improved sperm parameters, restored testicular histology, preserved membrane phospholipid composition, and normalized levels of steroid hormones including testosterone, estradiol, progesterone, and cortisol. It also prevented body weight loss induced by BPA. Although Vit E provided better protection of tubule structure, EOMC at 200\u2009mg\/kg offered broader benefits across multiple reproductive parameters. These findings highlight the therapeutic potential of high\u2010dose EOMC in mitigating BPA\u2010induced male reproductive toxicity and support its use as a natural protective agent.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70628","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T12:03:21Z","timestamp":1761221001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>Myrtus communis<\/i>\n                    essential oil mitigates bisphenol A\u2010induced reproductive and lipidomic alterations in a male rat model"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8418-9427","authenticated-orcid":false,"given":"Mhimdi","family":"Mariem","sequence":"first","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Ressources Higher Institute of Biotechnology of Beja University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9861-5780","authenticated-orcid":false,"given":"Selmi","family":"Slimen","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Ressources Higher Institute of Biotechnology of Beja University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sut","family":"Stefania","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peron","family":"Gregorio","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine (DMMT) University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8513-9372","authenticated-orcid":false,"given":"Jridi","family":"Mourad","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Ressources Higher Institute of Biotechnology of Beja University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dallacqua","family":"Stefano","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebai","family":"Hichem","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Ressources Higher Institute of Biotechnology of Beja University of Jendouba  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-091302-2.50032-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2018.12.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-58545-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16101343"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.6397"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-023-03614-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12559"},{"key":"e_1_2_9_10_1","volume-title":"Methods in enzymology","author":"Draper H. 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