{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T07:17:46Z","timestamp":1771312666185,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100015007","name":"RES\u2019EAU-WaterNET","doi-asserted-by":"publisher","award":["ALLRP\u2010597708\u201024"],"award-info":[{"award-number":["ALLRP\u2010597708\u201024"]}],"id":[{"id":"10.13039\/501100015007","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","award":["ERP\u20102024\u201014025"],"award-info":[{"award-number":["ERP\u20102024\u201014025"]}],"id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The optimization of cerebral perfusion and sedation using autoregulation\u2010derived physiologic targets such as optimal cerebral perfusion pressure (CPPopt), optimal mean arterial pressure (MAPopt), and optimal bispectral index (BISopt) has emerged as a promising strategy in neurocritical and perioperative care. However, the reliability and comparability of these optimal (Opt) parameters across different autoregulatory indices remain uncertain. This paper systematically reviews and synthesizes literature comparing CPPopt, MAPopt, and BISopt derived from invasive and noninvasive indices. Following PRISMA\u2010ScR guidelines, studies directly comparing CPPopt, MAPopt, or BISopt from at least two indices were included. Ten studies compared CPPopt, mostly in traumatic brain injury, with mean values between 70 and 76\u2009mmHg. Nine studies compared MAPopt, reporting strong correlations between transcranial doppler\u2010, near\u2010infrared spectroscopy\u2010, and intracranial pressure\u2010derived indices across populations, though limits of agreement were wide. One study compared BISopt across indices, showing internal consistency, while two cross\u2010Opt studies found little correlation between BISopt and CPPopt or MAPopt. CPPopt and MAPopt appear physiologically robust across indices, supporting translational potential in both invasive and noninvasive settings. BISopt may represent a distinct optimization domain related to sedation rather than perfusion. Methodological heterogeneity and limited outcome validation remain barriers. Future work should emphasize standardization, multimodal integration, and outcome\u2010driven trials.<\/jats:p>","DOI":"10.14814\/phy2.70660","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T07:38:49Z","timestamp":1766216329000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intercerebral autoregulation index consistency in the derivation of\n                    <scp>CPPopt<\/scp>\n                    ,\n                    <scp>MAPopt<\/scp>\n                    , and\n                    <scp>BISopt<\/scp>\n                    in humans: A scoping review"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2236-0245","authenticated-orcid":false,"given":"Rakibul","family":"Hasan","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Price Faculty of Engineering University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Zhang","sequence":"additional","affiliation":[{"name":"Undergraduate Genetics Program, Faculty of Science University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5983-008X","authenticated-orcid":false,"given":"Kevin Y.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Price Faculty of Engineering University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Undergraduate Medical Education, Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4395-7156","authenticated-orcid":false,"given":"Angela","family":"Buchel","sequence":"additional","affiliation":[{"name":"Undergraduate Medical Education, Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1082-6485","authenticated-orcid":false,"given":"Tobias","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Price Faculty of Engineering University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3231-5683","authenticated-orcid":false,"given":"Amanjyot Singh","family":"Sainbhi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Price Faculty of Engineering University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2764-145X","authenticated-orcid":false,"given":"Nuray","family":"Vakitbilir","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Price Faculty of Engineering University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isuru","family":"Herath","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Price Faculty of Engineering University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3860-8134","authenticated-orcid":false,"given":"Noah","family":"Silvaggio","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1131-2398","authenticated-orcid":false,"given":"Mansoor","family":"Hayat","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8062-0570","authenticated-orcid":false,"given":"Jaewoong","family":"Moon","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1737-0510","authenticated-orcid":false,"given":"Frederick A.","family":"Zeiler","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Price Faculty of Engineering University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Section of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Pan Am Clinic Foundation  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0b013e3182514eb6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877\u2010023\u201001009\u20101"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010024\u201002168\u2010y"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010015\u20100200\u20103"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1179\/1743132812Y.0000000145"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010025\u201005458\u20109"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.70332"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701\u2010019\u201004169\u20109"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010024\u201002088\u2010x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1751143720980273"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.3.JNS131500"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010014\u20100103\u20108"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00409"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164107X172167"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.3.3.031411"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40635\u2010022\u201000460\u20109"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/cce.0000000000000656"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877\u2010024\u201001136\u20103"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000790"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2020.03.016"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000930"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.132"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.10.JNS14602"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1959.39.2.183"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2022.03.029"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002348"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.662839"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/cce.0000000000001111"},{"key":"e_1_2_11_30_1","unstructured":"Moberg Analytics. (2025).The Future of Advanced Neuromonitoring.https:\/\/moberganalytics.com\/"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010016\u20101294\u20105"},{"key":"e_1_2_11_32_1","first-page":"133","volume-title":"Oxygen transport to tissue XLIII. Vol 1395. Advances in experimental medicine and biology","author":"Oshorov A.","year":"2022"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010009\u20109190\u20103"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010020\u201002974\u20108"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010017\u20100421\u20108"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000589"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201019101\u2010y"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701\u2010011\u20101148\u20105"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2016.05.019"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026282"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bas.2024.102835"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40635\u2010023\u201000579\u20103"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2025.1582813"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200204000-00002"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246\u2010023\u201003326\u20103"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00267.2016"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.7326\/m18\u20100850"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001798"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1155986"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010025\u201005432\u20105"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.6182"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1388"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.70660","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T06:46:28Z","timestamp":1771310788000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.70660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":52,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.14814\/phy2.70660"],"URL":"https:\/\/doi.org\/10.14814\/phy2.70660","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70660"}}