{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:04:58Z","timestamp":1764151498481,"version":"3.46.0"},"reference-count":58,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study examines sex\u2010specific effects of developmental sertraline exposure on cardiac function and gene expression before and after myocardial infarction (MI) in mice. Female C57BL\/6 mice (10\u2009weeks) received intraperitoneal sertraline (5\u2009mg\/kg\/day,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200937) or saline (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200920) before mating, during pregnancy, and postnatally to pups (1.5\u2009mg\/kg\/day, postnatal Days 0\u201314). MI in offspring was induced at 10\u2009weeks by left coronary artery ligation. Randomly chosen offspring (sham\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098 and MI\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200926 per sex) underwent baseline echocardiography and at 10\u2009weeks post\u2010MI if surviving. Serotonin\u2010 and estrogen\u2010related gene expression was analyzed. Before MI, sertraline\u2010exposed females had lower heart rate (649.1\u2009\u00b1\u2009102.0 vs. 692.9\u2009\u00b1\u200938.4\u2009bpm,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200934), increased end\u2010systolic volume, and reduced ejection fraction (80.7\u2009\u00b1\u20096.3% vs. 83.9\u2009\u00b1\u20093.5%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Exposed males also had lower heart rates (665.9\u2009\u00b1\u200932.7 vs. 683.3\u2009\u00b1\u200947.9\u2009bpm,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200934,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Post\u2010MI, both sexes remodeled similarly (scar size, ischemic\u2010zone fraction); sertraline\u2010exposed males had higher scar\u2010zone collagen (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and a nonsignificant lower survival trend than females. Sertraline altered serotonin\u2010related gene expression (\n                    <jats:italic>Htr2a<\/jats:italic>\n                    ,\n                    <jats:italic>Htr2b<\/jats:italic>\n                    ,\n                    <jats:italic>Slc6a4<\/jats:italic>\n                    ), particularly in male sham mice. Developmental sertraline exposure induces sex\u2010specific cardiac changes, potentially affecting post\u2010MI outcomes, with males showing more structural and survival impairments.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70662","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T04:41:44Z","timestamp":1763181704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sertraline exposure during development may impact post\u2010myocardial infarction survival in adult mice"],"prefix":"10.14814","volume":"13","author":[{"given":"Yongjun","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Iowa Carver College of Medicine  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Kenkel","sequence":"additional","affiliation":[{"name":"Bristol\u2010Myers Squibb  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa Carver College of Medicine  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa Carver College of Medicine  Iowa City Iowa USA"},{"name":"Department of Veteran Affairs Medical Center  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Roghair","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Iowa Carver College of Medicine  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4369-2652","authenticated-orcid":false,"given":"Sarah E.","family":"Haskell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Iowa Carver College of Medicine  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2015.05.008"},{"key":"e_1_2_10_3_1","first-page":"1","article-title":"Sex\u2010related differences in ventricular remodeling after myocardial infarction","volume":"334","author":"Aimo A.","year":"2021","journal-title":"International Journal of Cardiology"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.236927"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2016.08.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-11-16"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2199-11-22"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2012.10.002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00031-10"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2024.107689"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adc9606"},{"key":"e_1_2_10_12_1","first-page":"571","article-title":"Formation of binucleated myocardial cells in the neonatal rat. 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