{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:29:52Z","timestamp":1780450192166,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","award":["1911\u201003329"],"award-info":[{"award-number":["1911\u201003329"]}],"id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The prevalence and incidence of Crohn's disease (CD) in pediatric populations have been steadily increasing. Growing evidence suggests that gut microbiomal community differences play a critical role in the pathogenesis of CD. Additionally, the clinical course of patients with CD is unpredictable, making treatment decisions challenging. We investigated the fecal microbiome of newly diagnosed, treatment\u2010na\u00efve pediatric CD patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200943) compared to age\u2010 and sex\u2010matched controls with other functional gastrointestinal disorders (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009139). We also correlated microbial changes with CD disease activity, measured by the Pediatric Crohn's Disease Activity Index (PCDAI). Our results showed that microbial richness and diversity were significantly lower in CD patients. Furthermore, taxonomic analysis revealed an enrichment in pro\u2010inflammatory bacteria (\n                    <jats:italic>Fusobacteria<\/jats:italic>\n                    and\n                    <jats:italic>Proteobacteria<\/jats:italic>\n                    ) and depletion in favorable bacteria (\n                    <jats:italic>Firmicutes<\/jats:italic>\n                    and\n                    <jats:italic>Verrucomicrobia<\/jats:italic>\n                    ). Higher PCDAI scores were linked to the enrichment of genera harboring pro\u2010inflammatory taxa (\n                    <jats:italic>Hungatella<\/jats:italic>\n                    and\n                    <jats:italic>Veillonella<\/jats:italic>\n                    ) and decreased abundance of genera harboring protective taxa (\n                    <jats:italic>Lachnospiraceae<\/jats:italic>\n                    ). Our study underscores the potential of fecal microbiome profiling as an effective tool for understanding CD pathogenesis, identifying microbial biomarkers, and predicting disease activity for treatment response. This, in turn, can help to improve personalized treatment and management strategies in pediatric CD.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70665","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T05:20:52Z","timestamp":1767417652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Microbial signature of pediatric Crohn's disease: Differentiation from functional gastrointestinal disorders and relationship with increased disease activity"],"prefix":"10.14814","volume":"14","author":[{"given":"Jeremiah","family":"Levine","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology NYU Grossman School of Medicine  New York New York USA"},{"name":"Department of Pediatrics NYU Grossman School of Medicine  New York New York 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirali","family":"Thakor","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathobiology NYU Dentistry  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly","family":"Joseph","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology NYU Grossman School of Medicine  New York New York USA"},{"name":"Department of Pediatrics NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Trasande","sequence":"additional","affiliation":[{"name":"Department of Pediatrics NYU Grossman School of Medicine  New York New York USA"},{"name":"Department of Environmental Medicine NYU Grossman School of Medicine  New York New York USA"},{"name":"NYU Wagner School of Public Service  New York New York USA"},{"name":"NYU College of Global Public Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5506-5827","authenticated-orcid":false,"given":"Deepak","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathobiology NYU Dentistry  New York New York USA"},{"name":"Department of Surgery New York University Grossman School of Medicine  New York New York USA"},{"name":"Perlmutter Cancer Institute New York University Langone Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4526"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(18)30003\u20107"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.188383"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.016"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goy006"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010019\u20100209\u20109"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad9948"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.08.001"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjac155"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/904307"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20103207(92)91201\u20103"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00248\u2010021\u201001697\u20109"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.02.005"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i30.5100"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2178797"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2012.00040"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000183350.46795.42"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201055290\u20109"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6110099"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101237\u20109"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjv147"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14384"},{"key":"e_1_2_11_25_1","first-page":"235","article-title":"Phyloseq: 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