{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T07:17:48Z","timestamp":1771312668673,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cerebrovascular CYP450 is underexplored in humans. Twenty\u2010three participants (12 females) completed familiarization and two experimental visits utilizing double\u2010blind, randomized, crossover design. Participants ingested fluconazole (150\u2009mg; FLZ, CYP450 inhibitor) or placebo (PLC, microcrystalline cellulose) followed by 120\u2009min of supine rest. Five minutes of middle cerebral artery velocity (MCAv) and mean arterial pressure (MAP) were collected during rest (PLC\/FLZ\n                    <jats:sub>BASE<\/jats:sub>\n                    ) and lower body negative pressure (LBNP; \u221220\u2009mmHg; PLC\/FLZ\n                    <jats:sub>LBNP<\/jats:sub>\n                    ). There was no interaction for MCAv, cerebrovascular conductance index (CVCi), resistance area product (RAP), critical closing pressure (CrCP), or transfer function variables. Bonferroni tests revealed only FLZ attenuated MCAv (FLZ\n                    <jats:sub>BASE<\/jats:sub>\n                    75.2\u2009\u00b1\u200911.3\u2009cm\u2022s\n                    <jats:sup>\u22121<\/jats:sup>\n                    vs. FLZ\n                    <jats:sub>LBNP<\/jats:sub>\n                    70.6\u2009\u00b1\u200911.2\u2009cm\u2022s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.015,\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.713) and CVCi (FLZ\n                    <jats:sub>BASE<\/jats:sub>\n                    0.76\u2009\u00b1\u20090.12\u2009cm\u2022s\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u2022mmHg\n                    <jats:sup>\u22121<\/jats:sup>\n                    vs. FLZ\n                    <jats:sub>LBNP<\/jats:sub>\n                    0.71\u2009\u00b1\u20090.11\u2009cm\u2022s\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u2022mmHg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ,\n                    <jats:italic>p\u2009=<\/jats:italic>\n                    \u20090.003,\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.865) during LBNP. LBNP lowered CrCP (PLC\n                    <jats:sub>BASE<\/jats:sub>\n                    29.7\u2009\u00b1\u20099.3\u2009mmHg vs. PLC\n                    <jats:sub>LBNP<\/jats:sub>\n                    25.1\u2009\u00b1\u200911.3\u2009mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002,\n                    <jats:italic>d\u2009=<\/jats:italic>\n                    \u20090.940) within PLC. RAP increased during LBNP (PLC\n                    <jats:sub>BASE<\/jats:sub>\n                    0.96\u2009\u00b1\u20090.29 vs. PLC\n                    <jats:sub>LBNP<\/jats:sub>\n                    1.08\u2009\u00b1\u20090.32,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009&lt;\u20090.001,\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20091.28; FLZ\n                    <jats:sub>BASE<\/jats:sub>\n                    0.98\u2009\u00b1\u20090.24 vs. FLZ\n                    <jats:sub>LBNP<\/jats:sub>\n                    1.07\u2009\u00b1\u20090.23,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009&lt;\u20090.001,\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20091.10). These data suggest a participatory, nonobligatory role of CYP450 in human cerebrovascular control.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70712","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T07:40:58Z","timestamp":1766216458000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effects of\n                    <scp>CYP450<\/scp>\n                    inhibition on cerebrovascular control during rest and mild hypovolemia: An exploratory study in young, healthy adults"],"prefix":"10.14814","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1969-4639","authenticated-orcid":false,"given":"Jacob E.","family":"Matney","sequence":"first","affiliation":[{"name":"Human Circulation Research Laboratory, Department of Health and Exercise Science University of Oklahoma  Norman Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0743-391X","authenticated-orcid":false,"given":"Alexander A.","family":"Buelow","sequence":"additional","affiliation":[{"name":"Human Circulation Research Laboratory, Department of Health and Exercise Science University of Oklahoma  Norman Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4065-0301","authenticated-orcid":false,"given":"Chris","family":"Mixon","sequence":"additional","affiliation":[{"name":"Human Circulation Research Laboratory, Department of Health and Exercise Science University of Oklahoma  Norman Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5163-8253","authenticated-orcid":false,"given":"Sarah M.","family":"Skillett","sequence":"additional","affiliation":[{"name":"Human Circulation Research Laboratory, Department of Health and Exercise Science University of Oklahoma  Norman Oklahoma USA"},{"name":"Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0836-424X","authenticated-orcid":false,"given":"John D.","family":"Ashley","sequence":"additional","affiliation":[{"name":"Human Circulation Research Laboratory, Department of Health and Exercise Science University of Oklahoma  Norman Oklahoma USA"},{"name":"Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas  Dallas Texas USA"},{"name":"Department of Neurology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiwon","family":"Song","sequence":"additional","affiliation":[{"name":"Human Circulation Research Laboratory, Department of Health and Exercise Science University of Oklahoma  Norman Oklahoma USA"},{"name":"Department of Kinesiology, Health Promotion, and Recreation University of North Texas  Denton Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0686-8121","authenticated-orcid":false,"given":"Amir","family":"Akbari Fakhrabadi","sequence":"additional","affiliation":[{"name":"Human Circulation Research Laboratory, Department of Health and Exercise Science University of Oklahoma  Norman Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige","family":"Pointer","sequence":"additional","affiliation":[{"name":"Human Circulation Research Laboratory, Department of Health and Exercise Science University of Oklahoma  Norman Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9782-1865","authenticated-orcid":false,"given":"Justin D.","family":"Sprick","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Health Promotion, and Recreation University of North Texas  Denton Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher D.","family":"Black","sequence":"additional","affiliation":[{"name":"Sensory and Muscle Function Research Laboratory, Department of Health and Exercise Science University of Oklahoma  Norman Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4373-7005","authenticated-orcid":false,"given":"Hugo M.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Human Movement and Neurophysiology Research Laboratory, Department of Health and Exercise Science University of Oklahoma  Norman Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7889-8146","authenticated-orcid":false,"given":"J. Mikhail","family":"Kellawan","sequence":"additional","affiliation":[{"name":"Human Circulation Research Laboratory, Department of Health and Exercise Science University of Oklahoma  Norman Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.45"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.57.6.0769"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.4.H1541"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.5.1066"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.1992.tb09749.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2016.04.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14622"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13803"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00173.2024"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","DOI":"10.4199\/C00005ED1V01Y200912ISP002","volume-title":"The Cerebral Circulation","author":"Cipolla M.","year":"2009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2020"},{"key":"e_1_2_10_13_1","volume-title":"Basic Neurochemistry: Molecular, Cellular, Medical Aspects","author":"Clarke D.","year":"1999"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2217\/WHE.11.26"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000167273"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010010\u20108104\u2010x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000189600.74157.6d"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.1.60"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2009.02428.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010199039060\u201000006"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005293"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1994.266.5.H2098"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2015.12.007"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X231172854"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.02.016"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/1677\u20105449.210038"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.356822"},{"key":"e_1_2_10_29_1","first-page":"A34","article-title":"The role of cytochrome P450 metabolites as an endothelium\u2010derived hyperpolarising factor in the regulation of vascular tone in\u00a0vivo in the forearm vasculature of healthy and diabetic individuals","volume":"96","author":"Ozkor M. A.","year":"2010","journal-title":"Heart"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350\u20104533(03)00027\u20104"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221119760"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00498.2024"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X211004131"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967\u20103334\/32\/4\/007"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1963.18.5.924"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00698.2020"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.040073"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c140058"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2001"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100042\u20101758648"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.7.1672"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP280118"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080544"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00264.2015"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.9.3559"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12881"},{"key":"e_1_2_10_47_1","first-page":"112","article-title":"Transcranial Doppler evaluation of blood flow velocity changes in basal cerebral arteries in cerebral AVMs following embolisation and surgery","volume":"48","author":"Tyagi S. K.","year":"2000","journal-title":"Neurology India"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.110.152066"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00651.2014"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.2.467"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.01.011"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.3.H893"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2009.05.013"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70712","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.70712","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T06:46:34Z","timestamp":1771310794000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.70712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":52,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.14814\/phy2.70712"],"URL":"https:\/\/doi.org\/10.14814\/phy2.70712","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70712"}}