{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:51:25Z","timestamp":1768560685203,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA028537"],"award-info":[{"award-number":["AA028537"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA028537\u2010Supplement"],"award-info":[{"award-number":["AA028537\u2010Supplement"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The purpose of this cross\u2010sectional study was to determine the effect of at\u2010risk drinking on central hemodynamics and aortic stiffness in midlife adults. A total of 38 midlife men and 41 postmenopausal women, aged 50\u201064 and free of major clinical diseases, were included. Based on USAUDIT\u2010C scores derived from the U.S. Alcohol Use Disorder Identification Test, participants were classified as low\u2010risk drinkers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200950) or at\u2010risk drinkers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200929). Central blood pressure (BP), aortic wave reflection indices, as well as carotid\u2010to\u2010femoral pulse wave velocity (cfPWV; a measure of aortic stiffness) were measured. Regardless of sex (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.11 for both), among participants free of antihypertensive medications (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200951), at\u2010risk drinkers had higher central systolic (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) and diastolic BP (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) compared with low\u2010risk drinkers, while there was no between\u2010group difference in central BP among treated participants (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200928;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2265\u20090.41). Among untreated participants, higher USAUDIT\u2010C scores remained independently associated with elevated systolic (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and diastolic BP (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003), after controlling for wave reflection indices and cfPWV. Regardless of antihypertensive medication use (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2265\u20090.25) and sex (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2265\u20090.10), no between\u2010group differences were observed in aortic wave reflection indices (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2265\u20090.18) and cfPWV (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.16). These findings suggest that elevated central BP associated with at\u2010risk drinking is related to mechanisms other than enhanced aortic wave reflection or aortic stiffening.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70717","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T04:31:23Z","timestamp":1768192283000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of at\u2010risk drinking on central hemodynamics and aortic stiffness in midlife adults"],"prefix":"10.14814","volume":"14","author":[{"given":"Keng\u2010Yu","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Kinesiology University of Texas at Arlington  Arlington Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoli","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Nursing and Health Innovation University of Texas at Arlington  Arlington Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitesh","family":"Nirmal","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Texas at Arlington  Arlington Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2830-4482","authenticated-orcid":false,"given":"Brooks A.","family":"Hibner","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Nutrition University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maysa","family":"Nashawati","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Texas at Arlington  Arlington Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John O.","family":"Kolade","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Texas at Arlington  Arlington Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeonwoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Texas at Arlington  Arlington Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3281-5277","authenticated-orcid":false,"given":"R. Matthew","family":"Brothers","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Texas at Arlington  Arlington Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane A.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-4802","authenticated-orcid":false,"given":"Chueh\u2010Lung","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Kinesiology University of Texas at Arlington  Arlington Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agl078"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2020.08.013"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.063"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.124.22703"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.70021"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024\u20103205(91)90538\u2010m"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agt040"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.21224"},{"key":"e_1_2_11_10_1","unstructured":"Dietary Guidelines for Americans. (2020).2020\u20132025 Dietary Guidelines for Americans 49."},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.03.041"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13838"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000530823"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1997.tb03744.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13859"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.40717"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012\u2010022\u201009728\u20108"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14872"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2013.144"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001356"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0895\u20107061(01)02315\u20109"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001303"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000093435.04334.1F"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000128420.01881.aa"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001341"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000110784.52412.8f"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000503342"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq024"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.061"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70717","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.70717","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T18:17:49Z","timestamp":1768501069000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.70717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.14814\/phy2.70717"],"URL":"https:\/\/doi.org\/10.14814\/phy2.70717","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70717"}}