{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:19:48Z","timestamp":1790018388268,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study was motivated by the limited high\u2010altitude physiology data available for Asian military aviators, especially in Vietnam. To characterize acute heart rate (HR), blood pressure (BP), and oxygen saturation (SpO\n                    <jats:sub>2<\/jats:sub>\n                    ) responses in healthy Vietnamese pilots during simulated 5000\u2009m hypobaric exposure. Seventy\u2010five healthy male military pilots underwent 30\u2010min exposure in a hypobaric chamber simulating 5000\u2009m altitude. HR, systolic\/diastolic BP (SBP\/DBP), and SpO\n                    <jats:sub>2<\/jats:sub>\n                    were recorded at baseline (0\u2009m), peak altitude, and post\u2010exposure. HR increased from 80.0\u2009\u00b1\u20099.0 to 91.9\u2009\u00b1\u200911.0\u2009bpm, SBP\/DBP rose by 10.4\/6.5\u2009mmHg, and SpO\n                    <jats:sub>2<\/jats:sub>\n                    decreased from 98.4\u2009\u00b1\u20091.0% to 77.7\u2009\u00b1\u20096.0% (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). All changes were transient, returning to baseline within 5\u2009min after exposure, and no adverse events occurred. Higher baseline HR and older age predicted smaller HR increases. Acute 5000\u2009m hypobaric hypoxia caused transient tachycardia, hypertension, and hypoxemia. Response variability correlated with baseline hemodynamic status and age. This safe, reproducible model can serve as a noninvasive cardiovascular stress test in clinical and aerospace medicine.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70733","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T04:50:41Z","timestamp":1770871841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Heart rate, blood pressure, and\n                    <scp>SpO<\/scp>\n                    <sub>2<\/sub>\n                    responses to simulated 5000\u2009m hypobaric exposure in healthy male Vietnamese pilots"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8042-7013","authenticated-orcid":false,"given":"Xuan Nguyen","family":"Thanh","sequence":"first","affiliation":[{"name":"103 Military Hospital, Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phong Nguyen","family":"Hong","sequence":"additional","affiliation":[{"name":"Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan Tran","family":"Ngoc","sequence":"additional","affiliation":[{"name":"Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong Nguyen","family":"Minh","sequence":"additional","affiliation":[{"name":"Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toan Pham","family":"Quoc","sequence":"additional","affiliation":[{"name":"103 Military Hospital, Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toan Nguyen","family":"Duy","sequence":"additional","affiliation":[{"name":"103 Military Hospital, Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thao Pham","family":"Ngoc","sequence":"additional","affiliation":[{"name":"103 Military Hospital, Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thong Nguyen","family":"Huy","sequence":"additional","affiliation":[{"name":"103 Military Hospital, Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyen Nguyen","family":"Van","sequence":"additional","affiliation":[{"name":"103 Military Hospital, Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6378-4429","authenticated-orcid":false,"given":"Thuc Luong","family":"Cong","sequence":"additional","affiliation":[{"name":"103 Military Hospital, Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/s24134168"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.01049"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.4274\/hamidiyemedj.galenos.2021.29291"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.70028"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2006.02.005"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.25259\/IJASM_19_2021","article-title":"Hypoxia signature: A useful tool for hypoxia recognition among aircrew","volume":"65","author":"Kasture S.","year":"2021","journal-title":"Indian Journal of Aerospace 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