{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:07:12Z","timestamp":1783836432354,"version":"3.55.0"},"reference-count":58,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Far\u2010from\u2010equilibrium thermodynamics were studied in patients with either lung cancer or pulmonary inflammatory diseases. Histological and mechanical activities were due to myofibroblasts. A study on isolated lung fragments treated with the Huxley formalism showed that mechanical abnormalities were similar in both groups: maximum velocity, isometric tension, maximum efficiency, force of non\u2010muscle (NM) myosin crossbridge (CB), time stroke (ts), rate constants for CB detachment, and catalytic constant. Only maximum myosin ATPase activity, myosin content, and CB attachment constant were higher in inflammatory processes than in cancers. Contractile samples were open systems. In each group, \u03b2\u2010catenin, NMIIA and B myosins were present. Thermodynamic force (TFo) and flow (TFl) did not show any significant difference between the two groups of patients. In both groups, TFo varied nonlinearly with TFl. This showed that these two systems behaved far\u2010from\u2010equilibrium. Entropy production rate was equal to the TFo \u00d7 TFl product and did not show any significant statistical difference between the two groups. Excess entropy production was negative in both groups which showed that they were self\u2010organized. In conclusion, the two groups of patients evolved towards self\u2010organized dissipative structures driven by TGF\u2010\u03b21, which created a tissue capable of contractility thanks to myofibroblasts generated by inflammation.<\/jats:p>","DOI":"10.14814\/phy2.70738","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:09:16Z","timestamp":1778692156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary parenchyma becomes a self\u2010organized dissipative structure in lung cancers and pulmonary inflammatory diseases"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0437-4862","authenticated-orcid":false,"given":"Yves","family":"Lecarpentier","sequence":"first","affiliation":[{"name":"Centre de Recherche Clinique Grand H\u00f4pital de l'Est Francilien  Meaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Morini","sequence":"additional","affiliation":[{"name":"Service d'Anatomie et Cytologie Pathologiques Grand H\u00f4pital de l'Est Francilien  Jossigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Thoracique et Vasculaire Grand H\u00f4pital de l'Est Francilien  Meaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christ\u00e8le","family":"Locher","sequence":"additional","affiliation":[{"name":"Service de Pneumologie Grand H\u00f4pital de l'Est Francilien  Meaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X\u00e9nophon","family":"Krokidis","sequence":"additional","affiliation":[{"name":"X\u00e9nomics  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Claes","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Antwerp  Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Schussler","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chirurgie Thoracique, H\u00f4pital Cochin, H\u00f4pitaux Universitaires Paris Centre Paris\u2010Descartes Universit\u00e9, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Locher","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie Grand H\u00f4pital de l'Est Francilien  Meaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.3.2099"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/360361a0"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.35.3.345"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00194701"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.56.7.549"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.007112"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0959-9673.2004.00377.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64926-7"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/e20120989"},{"key":"e_1_2_12_11_1","volume-title":"Endotext","author":"Fox\u2010Rabinovich G.","year":"2006"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(53)90082-1"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02147594"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/e25050771"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.1.197"},{"issue":"1","key":"e_1_2_12_16_1","first-page":"S44","article-title":"Origin of cyclicity in bipolar disorders: A computational approach","volume":"46","author":"Goldbeter A.","year":"2013","journal-title":"Pharmacopsychiatry"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.07.041"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(72)86164-2"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1938.0050"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.9.2730"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.02.004"},{"key":"e_1_2_12_22_1","first-page":"255","article-title":"Muscle structure and theories of contraction","volume":"7","author":"Huxley A. F.","year":"1957","journal-title":"Progress in Biophysics & Molecular biology"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00779.x"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.17-0684"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118698723"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63289-0"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160943"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.10.007"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.11.981"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23136967"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.70483"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0298979"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01248"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13050427"},{"issue":"7","key":"e_1_2_12_35_1","first-page":"845","article-title":"Kinetic study of carcinogenesis. Diffusion of cytotoxic cells and the behavior at the threshold of cancer","volume":"285","author":"Lefever R.","year":"1977","journal-title":"Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences Serie D"},{"issue":"10","key":"e_1_2_12_36_1","first-page":"1876","article-title":"Elevated levels of platelet derived growth factor and transforming growth factor\u2010beta 1 in bronchoalveolar lavage fluid from patients with scleroderma","volume":"22","author":"Ludwicka A.","year":"1995","journal-title":"The Journal of Rheumatology"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.139.6.1477"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/e22030372"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-005216-5.50010-4"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.12.6060"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02797383"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/223913a0"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1974.tb20557.x"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8316858"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319270"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.5.854"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/372515a0"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1927.sp002355"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20215"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm809"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8240(05)80008-4"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-019-0362-3"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874312901206010103"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34424"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2008.85"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1047"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00716-0"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.165848"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00151.2001"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70738","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.70738","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:11:41Z","timestamp":1783833101000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.70738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.14814\/phy2.70738"],"URL":"https:\/\/doi.org\/10.14814\/phy2.70738","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70738"}}