{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:08:34Z","timestamp":1783840114742,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study investigated the influence of diabetic peripheral neuropathy (DPN) on physical performance in older adults with type 2 diabetes mellitus (T2DM) following a combined training (CT) program. A total of 51 older adults participated in the study divided into DPN (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200924) and non\u2010DPN (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200927) groups. Muscle strength was assessed by handgrip strength; physical performance by the Short Physical Performance Battery, and the Senior Fitness Test (SFT); and balance by the Timed Up and Go (TUG) test, with and without a cognitive task. The CT program lasted 12\u2009weeks, with two weekly sessions including resistance exercises for major muscle groups and high\u2010intensity interval aerobic training on a stationary bicycle. Compared with the DPN group, the non\u2010DPN group showed greater improvements in agility and dynamic balance in the SFT (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.010) and TUG (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.018). BMI and diabetes duration explained 15% of the variance in the 30\u2010s chair stand. DPN presence explained 13% of the variance in SFT agility and balance and 20% in TUG, while age and BMI explained 12% of the variance in the 4\u2009m walk test. DPN attenuates the response to combined training, particularly affecting functional outcomes related to mobility and balance.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70755","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:42:11Z","timestamp":1780638131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Can diabetic peripheral neuropathy influence the final outcome of physical performance after a combined training program in older adults? A double\u2010blind quasi\u2010experimental study"],"prefix":"10.14814","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2384-3994","authenticated-orcid":false,"given":"Matheus Henrique dos Santos","family":"Lino","sequence":"first","affiliation":[{"name":"Graduate Program in Aging Sciences University S\u00e3o Judas Tadeu  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0249-7666","authenticated-orcid":false,"given":"Marcus Vinicius","family":"Grecco","sequence":"additional","affiliation":[{"name":"The Movement Study Laboratory of the Hospital das Cl\u00ednicas The School of Medicine of the University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6346-0317","authenticated-orcid":false,"given":"Eneida Yuri","family":"Suda","sequence":"additional","affiliation":[{"name":"Graduate Program in Physical Therapy University Ibirapuera  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-9232","authenticated-orcid":false,"given":"Sara Rodrigues","family":"Rosado","sequence":"additional","affiliation":[{"name":"The Undergraduate Nursing Program University Center S\u00e3o Camilo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3164-3223","authenticated-orcid":false,"given":"Andr\u00e9 Luiz","family":"de Seixas Soares","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute, Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5741-3418","authenticated-orcid":false,"given":"Adriana Machado Saldiba","family":"de Lima","sequence":"additional","affiliation":[{"name":"Graduate Program in Aging Sciences University S\u00e3o Judas Tadeu  S\u00e3o Paulo Brazil"},{"name":"The Movement Study Laboratory of the Hospital das Cl\u00ednicas The School of Medicine of the University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0403-0632","authenticated-orcid":false,"given":"Guilherme Carlos","family":"Brech","sequence":"additional","affiliation":[{"name":"Graduate Program in Aging Sciences University S\u00e3o Judas Tadeu  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1778-0448","authenticated-orcid":false,"given":"Julia Maria","family":"D'Andr\u00e9a Greve","sequence":"additional","affiliation":[{"name":"The Movement Study Laboratory of the Hospital das Cl\u00ednicas The School of Medicine of the University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9644-5068","authenticated-orcid":false,"given":"Angelica Castilho","family":"Alonso","sequence":"additional","affiliation":[{"name":"Graduate Program in Aging Sciences University S\u00e3o Judas Tadeu  S\u00e3o Paulo Brazil"},{"name":"The Movement Study Laboratory of the Hospital das Cl\u00ednicas The School of Medicine of the University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0274754"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2018\/e303"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198185"},{"key":"e_1_2_11_5_1","first-page":"997","volume-title":"Avalia\u00e7\u00e3o e reeduca\u00e7\u00e3o proprioceptiva in: tratado medicina de reabilita\u00e7\u00e3o","author":"Alonso A. C.","year":"2007"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181915670"},{"key":"e_1_2_11_7_1","volume-title":"Endotext [Internet]","author":"Anandhanarayanan A.","year":"2000"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2005.07.005"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2020\/e1628"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1519\/00139143\u2010200608000\u201000004"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15053"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(12)70065\u20100"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23\u2010er05"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/1413\u2010785220202806234529"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.638936"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinsp.2024.100504"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.10.041"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12841"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10215042"},{"key":"e_1_2_11_20_1","volume-title":"Guidelines on the prevention and management of diabetic foot disease","author":"International Working Group on the Diabetic Foot","year":"2019"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010021\u201005646\u20106"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20160124"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2011.07.014"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1519\/R\u201017224.1"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212921"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010017\u20104253\u2010z"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/1809\u20102950\/14649323022016"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.31128\/AJGP\u201006\u201022\u20106456"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/1517\u2010869220202605219295"},{"key":"e_1_2_11_30_1","volume-title":"Vers\u00e3o brasileira da Short Physical Performance Battery SPPB: adapta\u00e7\u00e3o cultural e estudo da confiabilidade. Campinas, Dissertation (Master in Gerontology)","author":"Nakano M. M.","year":"2007"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.70123"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glz257"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004\u2010282X20160094"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.5935\/0101\u20102800.20160006"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6978128"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24310"},{"key":"e_1_2_11_37_1","volume-title":"Diretrizes da Sociedade Brasileira de Diabetes 2023\u20132024","author":"Sociedade Brasileira de Diabetes","year":"2023"},{"key":"e_1_2_11_38_1","volume-title":"Diretrizes da SBD 2023\u20132024","author":"Sociedade Brasileira de Diabetes","year":"2023"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279\u2010021\u201001596\u20106"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2016.08.006"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300\u2010023\u201001510\u20105"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2010.09.030"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010019\u201004979\u20107"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u20100003\u201011\u201011"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70755","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.70755","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.70755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:51:44Z","timestamp":1783839104000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.70755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.14814\/phy2.70755"],"URL":"https:\/\/doi.org\/10.14814\/phy2.70755","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70755"}}